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  Publication History of Lewis E. Kay        
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1.J. Gariépy, Lewis E. Kay, I.D. Kuntz, B.D. Sykes and R.S. Hodges. Nuclear Magnetic Resonance Determination of Metal-Proton Distances in a Synthetic Calcium Binding Site of Rabbit Skeletal Troponin C. Biochemistry 24, 544-550 (1985). (1.pdf) (DOI) (pubmed)

2.D.C. Corson, T.C. Williams, Lewis E. Kay and B.D. Sykes. 1H NMR Spectroscopic Studies of Calcium Binding Proteins. 1. Stepwise Proteolysis of the C-Terminal α-Helix of a Helix-Loop-Helix Metal-Binding Domain. Biochemistry 25, 1817-1826 (1986). (2.pdf) (DOI) (pubmed)

3.Lewis E. Kay and J.H. Prestegard. An Application of Pulse-Gradient Double-Quantum Spin Echoes to Diffusion Measurements on Molecules with Scalar-Coupled Spins. J. Magn. Reson. 67, 103-113 (1986). (3.pdf) (DOI)

4.Lewis E. Kay, J.N. Scarsdale, D.R. Hare and J.H. Prestegard. Simulation of Two-Dimensional Cross-Relaxation Spectra in Strongly Coupled Spin Systems. J. Magn. Reson. 68, 515-525 (1986). (4.pdf) (DOI)

5.Lewis E. Kay, T.A. Holak, B.A. Johnson, I.M. Armitage and J.H. Prestegard. Second-Order Effects in Two-Dimensional Cross-Relaxation Spectra of Proteins: Investigation of Glycine Spin Systems. J. Am. Chem. Soc. 108, 4242-4244 (1986). (5.pdf) (DOI)

6.Lewis E. Kay, J.M. Pascone, B.D. Sykes and J.W. Shriver. 19F Nuclear Magnetic Resonance as a Probe of Structural Transitions and Cooperative Interactions in Heavy Meromyosin. J. Biol. Chem. 262, 1984-1988 (1987). (6.pdf) (DOI) (pubmed)

7.Lewis E. Kay and J.H. Prestegard. Methyl Group Dynamics from Relaxation of Double Quantum Filtered NMR Signals: Application to Deoxycholate. J. Am. Chem. Soc. 109, 3829-3835 (1987). (7.pdf) (DOI)

8.Lewis E. Kay, P.-J. Jones and J.H. Prestegard. Strong Coupling Effects in the Homonuclear RELAY Experiment, with Applications to Leucine Spin Systems of Octanoyl-Acyl Carrier Protein. J. Magn. Reson. 72, 392-396 (1987). (8.pdf) (DOI)

9.Lewis E. Kay, T.L. Jue, B. Bangerter and P.C. Demou. Sensitivity Enhancement of 13C T1 Measurements via Polarization Transfer. J. Magn. Reson. 73, 558-564 (1987). (9.pdf) (DOI)

10.Lewis E. Kay and R.E.D. McClung. A Product Operator Description of AB and ABX Spin Systems. J. Magn. Reson. 77, 258-273 (1988). (10.pdf) (DOI)

11.Lewis E. Kay, T.A. Holak and J.H. Prestegard. AX3 Spin System Dynamics from Forbidden Cross Peak Intensities in Double-Quantum Two-Dimensional Spectra, with Application to Acyl Carrier Protein. J. Magn. Reson. 76, 30-40 (1988). (11.pdf) (DOI)

12.Lewis E. Kay and J.H. Prestegard. Spin-Lattice Relaxation Rates of Coupled Spins from 2D Accordion Spectroscopy. J. Magn. Reson. 77, 599-605 (1988). (12.pdf) (DOI)

13.Lewis E. Kay and J.H. Prestegard. Simultaneous Measurement of 13C Multiplicities and 1H and 13C Chemical Shifts. J. Magn. Reson. 78, 172-177 (1988). (13.pdf) (DOI)

14.A.F. Frederick, Lewis E. Kay and J.H. Prestegard. Location of Divalent Ion Sites in Acyl Carrier Protein Using Relaxation Perturbed 2D NMR. FEBS Lett. 238, 43-48 (1988). (14.pdf) (DOI) (pubmed)

15.D.M. LeMaster, Lewis E. Kay, A.T. Brünger and J.H. Prestegard. Protein Dynamics and Distance Determination by NOE Measurements. FEBS Lett. 236, 71-76 (1988). (15.pdf) (DOI) (pubmed)

16.Lewis E. Kay, D.S. Thomson and J.H. Prestegard. Extraction of 1H-1H and 1H-13C Dipolar Couplings from Spectra Acquired in Inhomogeneous Magnetic Fields. Magn. Reson. Chem. 26, 860-866 (1988). (16.pdf) (DOI)

17.A. Bax, Lewis E. Kay, S.W. Sparks and D.A. Torchia. Line Narrowing of Amide Proton Resonances in 2D NMR Spectra of Proteins. J. Am. Chem. Soc. 111, 408-409 (1989). (17.pdf) (17_SI.pdf) (DOI)

18.D. Marion, Lewis E. Kay, S.W. Sparks, D.A. Torchia and A. Bax. Three-Dimensional Heteronuclear NMR of 15N-Labeled Proteins. J. Am. Chem. Soc. 111, 1515-1517 (1989). (18.pdf) (18_SI.pdf) (DOI)

19.Lewis E. Kay, D. Marion and A. Bax. Practical Aspects of 3D Heteronuclear NMR of Proteins. J. Magn. Reson. 84, 72-84 (1989). (19.pdf) (DOI)

20.Lewis E. Kay and A. Bax. Separation of NH and NH2 Resonances in 1H-Detected Heteronuclear Multiple-Quantum Correlation Spectra. J. Magn. Reson. 84, 598-603 (1989). (20.pdf) (DOI)

21.Lewis E. Kay, B. Brooks, S.W. Sparks, D.A. Torchia and A. Bax. Measurement of NH-CαH Coupling Constants in Staphylococcal Nuclease by Two-Dimensional NMR and Comparison with X-ray Crystallographic Results. J. Am. Chem. Soc. 111, 5488-5490 (1989). (21.pdf) (21_SI.pdf) (DOI)

22.D. Marion, P.C. Driscoll, Lewis E. Kay, P.T. Wingfield, A. Bax, A.M. Gronenborn and G.M. Clore. Overcoming the Overlap Problem in the Assignment of 1H NMR Spectra of Larger Proteins by Use of Three-Dimensional Heteronuclear 1H-15N Hartmann-Hahn-Multiple Quantum Coherence and Nuclear Overhauser-Multiple Quantum Coherence Spectroscopy: Application to Interleukin 1β. Biochemistry 28, 6150-6156 (1989). (22.pdf) (DOI) (pubmed)

23.Lewis E. Kay, D.A. Torchia and A. Bax. Backbone Dynamics of Proteins as Studied by 15N Inverse Detected Heteronuclear NMR Spectroscopy: Application to Staphylococcal Nuclease. Biochemistry 28, 8972-8979 (1989). (23.pdf) (23_SI.pdf) (DOI) (pubmed)

24.Lewis E. Kay and A. Bax. New Methods for the Measurement of NH-CαH Coupling Constants of 15N-Labeled Proteins. J. Magn. Reson. 86, 110-126 (1990). (24.pdf) (DOI)

25.J.D. Forman-Kay, A.M. Gronenborn, Lewis E. Kay, P.T. Wingfield and G.M. Clore. Studies on the Solution Conformation of Human Thioredoxin using Heteronuclear 15N-1H Nuclear Magnetic Resonance Spectroscopy. Biochemistry 29, 1566-1572 (1989). (25.pdf) (DOI) (pubmed)

26.A. Bax, M. Ikura, Lewis E. Kay, D.A. Torchia and R. Tschudin. Comparison of Different Modes of Two-Dimensional Reverse-Correlation NMR for the Study of Proteins. J. Magn. Reson. 86, 304-318 (1990). (26.pdf) (DOI)

27.M. Ikura, Lewis E. Kay, R. Tschudin and A. Bax. Three-Dimensional NOESY-HMQC Spectroscopy of a 13C-Labeled Protein. J. Magn. Reson. 86, 204-209 (1990). (27.pdf) (DOI)

28.Lewis E. Kay, M. Ikura and A. Bax. Proton-Proton Correlation via Carbon-Carbon Couplings: A Three-Dimensional NMR Approach for the Assignment of Aliphatic Resonances in Proteins Labeled with Carbon-13. J. Am. Chem. Soc. 112, 888-889 (1990). (28.pdf) (28_SI.pdf) (DOI)

29.D.A. Torchia, S.W. Sparks, H.B.R. Cole, D.M. Baldisseri, Lewis E. Kay, D. Marion and A. Bax. Assignments, Structure and Dynamics of Staphylococcal Nuclease. Polymer Preprints 31 135-136 (1990). (29_scan.pdf)

30.M. Ikura, Lewis E. Kay, D.A. Torchia, C. Klee and A. Bax. Novel Approaches for Obtaining Resonance Assignments of Larger Proteins. Polymer Preprints 31 133-134 (1990). (30_scan.pdf)

31.M. Ikura, D. Marion, Lewis E. Kay, H. Shih, M. Krinks, C.B. Klee and A. Bax. Heteronuclear 3D NMR and Isotopic Labeling of Calmodulin: Towards the Complete Assignment of the 1H NMR Spectrum. Biochem. Pharmacol. 40, 153-160 (1990). (31.pdf) (DOI) (pubmed)

32.M. Ikura, Lewis E. Kay and A. Bax. A Novel Approach for Sequential Assignment of 1H, 13C, and 15N Spectra of Larger Proteins: Heteronuclear Triple-Resonance Three-Dimensional NMR Spectroscopy. Application to Calmodulin. Biochemistry 29, 4659-4667 (1990). (32.pdf) (32_SI.pdf) (DOI) (pubmed)

33.A. Bax, G.M. Clore, P.C. Driscoll, A.M. Gronenborn, P.C. Driscoll, M. Ikura and Lewis E. Kay. Practical Aspects of Proton-Carbon-Carbon-Proton Three-Dimensional Correlation Spectroscopy of 13C Labeled Proteins. J. Magn. Reson. 87, 620-627 (1990). (33.pdf) (DOI)

34.G.M. Clore, A. Szabo, A. Bax, Lewis E. Kay, P.C. Driscoll and A.M. Gronenborn. Deviations from the Simple Two-Parameter Model-Free Approach to the Interpretation of Nitrogen-15 Nuclear Magnetic Relaxation of Proteins. J. Am. Chem. Soc. 112, 4989-4991 (1990). (34.pdf) (DOI)

35.Lewis E. Kay, M. Ikura, R. Tschudin and A. Bax. Three-Dimensional Triple-Resonance NMR Spectroscopy of Isotopically Labelled Proteins. J. Magn. Reson. 89, 496-514 (1990). (35.pdf) (DOI)

36.Lewis E. Kay, G.M. Clore, A. Bax and A.M. Gronenborn. Four-Dimensional Heteronuclear Triple-Resonance Spectroscopy of Interleukin-1β in Solution. Science 249, 411-414 (1990). (36.pdf) (DOI) (pubmed)

37.G.M. Clore, Lewis E. Kay, A. Bax and A.M. Gronenborn. Four-Dimensional 13C/13C-Edited Nuclear Overhauser Enhancement Spectroscopy of a Protein in Solution: Application to Interleukin-1β. Biochemistry (Accelerated) 30, 12-18 (1991). (37.pdf) (DOI) (pubmed)

38.A. Bax, M. Ikura, Lewis E. Kay and G. Zhu. Removal of F1 Baseline Distortion and Optimization of Folding in Multidimensional NMR Spectra. J. Magn. Reson. 91, 174-178 (1991). (38.pdf) (DOI)

39.Lewis E. Kay, M. Ikura and A. Bax. The Design and Optimization of Complex NMR Experiments: Application to a Triple-Resonance Pulse Scheme Correlating Hα, NH and 15N Chemical Shifts in 15N-13C Labeled Proteins. J. Magn. Reson. 91, 84-92 (1991). (39.pdf) (DOI)

40.Lewis E. Kay, M. Ikura, G. Zhu and A. Bax. Four-Dimensional Heteronuclear Triple-Resonance NMR of Isotopically Enriched Proteins for Sequential Assignment of Backbone Atoms. J. Magn. Reson. 91, 422-428 (1991). (40.pdf) (DOI)

41.R. Boelens, C. Griesinger, Lewis E. Kay, D. Marion and E.R.P. Zuiderweg. Applicability and Limitations of Three-Dimensional NMR Spectroscopy for the Study of Proteins in Solution. In “Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy”. Vol 225, pp 127-150, NATO ASI Series, Eds. J.C. Hoch, F.M. Poulsen, C. Redfield; Springer, Boston, MA (1991). (41_scan.pdf) (DOI)

42.Lewis E. Kay, J.D. Forman-Kay, W.D. McCubbin and C.M. Kay. Solution Structure of a Polypeptide Dimer Comprising the Fourth Ca2+-Binding Site of Troponin C by Nuclear Magnetic Resonance Spectroscopy. Biochemistry 30, 4323-4333 (1991). (42.pdf) (DOI) (pubmed)

43.M. Ikura, Lewis E. Kay, M. Krinks and A. Bax. A Triple-Resonance Multidimensional NMR Study of Calmodulin Complexed with the Binding Domain of Myosin Light-Chain Kinase: Indication of a Conformational Change in the Central Helix. Biochemistry 30, 5498-5504 (1991). (43.pdf) (43_SI.pdf) (DOI) (pubmed)

44.Lewis E. Kay and D.A. Torchia. The Effects of Dipolar Cross Correlation on 13C Methyl-Carbon T1, T2 and NOE Measurements in Macromolecules. J. Magn. Reson. 95, 536-547 (1991). (44.pdf) (DOI)

45.M. Ikura, S. Spera, G. Barbato, Lewis E. Kay, M. Krinks and A. Bax. Secondary Structure and Side-Chain 1H and 13C Resonance Assignments of Calmodulin by Heteronuclear Multidimensional NMR Spectroscopy. Biochemistry 30, 9216-9228 (1991). (45.pdf) (45_SI.pdf) (DOI) (pubmed)

46.M. Ikura, Lewis E. Kay and A. Bax. Improved Three-Dimensional 1H-13C-1H Correlation Spectroscopy of a 13C Labeled Protein Using Constant-Time Evolution. J. Biomol. NMR 1, 299-304 (1991). (46.pdf) (DOI) (pubmed)

47.A. Bax, M. Ikura, Lewis E. Kay, G. Barbato and S. Spera. Multidimensional Triple Resonance NMR Spectroscopy of Isotopically Uniformly Enriched Proteins: A Powerful New Strategy for Structure Determination. In “Protein Conformation”. pp 108-134, Ciba Foundation Symposium 161, Eds. D.J. Chadwick, K. Widdows, Wiley, Chichester (1991). (47.pdf) (DOI) (pubmed)

48.L.K. Nicholson, Lewis E. Kay, D.M. Baldisseri, J. Arango, P.E. Young, A. Bax and D.A. Torchia. Dynamics of Methyl Groups in Proteins as Studied by Proton-Detected 13C NMR Spectroscopy. Application to the Leucine Residues of Staphylococcal Nuclease. Biochemistry 31, 5253-5263 (1992). (48.pdf) (48_SI.pdf) (DOI) (pubmed)

49.Lewis E. Kay, L.K. Nicholson, F. Delaglio, A. Bax and D.A. Torchia. Pulse Sequences for Removal of the Effects of Cross Correlation Between Dipolar and Chemical-Shift Anisotropy Relaxation Mechanisms on the Measurement of Heteronuclear T1 and T2 Values in Proteins. J. Magn. Reson. 97, 359-375 (1992). (49.pdf) (DOI)

50.G. Barbato, M. Ikura, Lewis E. Kay, R.W. Pastor and A. Bax. Backbone Dynamics of Calmodulin Studied by 15N Relaxation Using Inverse Detected Two-Dimensional NMR Spectroscopy: The Central Helix is Flexible. Biochemistry 31, 5269-5278 (1992). (50.pdf) (50_SI.pdf) (DOI) (pubmed)

51.Lewis E. Kay, T.E. Bull, L.K. Nicholson, C. Griesinger, H. Scwalbe, A. Bax and D.A. Torchia. The Measurement of Heteronuclear Transverse Relaxation Times in AX3 Spin Systems via Polarization-Transfer Techniques. J. Magn. Reson. 100, 538-558 (1992). (51.pdf) (DOI)

52.Lewis E. Kay and T.E. Bull. Heteronuclear Transverse Relaxation in AMX, AX2 and AX3 Spin Systems. J. Magn. Reson. 99, 615-622 (1992). (52.pdf) (DOI)

53.Lewis E. Kay, M. Wittekind, M.A. McCoy, M.S. Friedrichs and L. Mueller. 4D Triple-Resonance Experiments for Assignment of Protein Backbone Nuclei Using Constant-Time Evolution Periods. J. Magn. Reson. 98, 443-450 (1992). (53.pdf) (DOI)

54.Lewis E. Kay, M. Ikura, A.A. Grey and D.R. Muhandiram. Three-Dimensional NMR Experiments for the Separation of Side-Chain Correlations in Proteins via the Carbonyl Chemical Shift. J. Magn. Reson. 99, 652-659 (1992). (54.pdf) (DOI)

55.Lewis E. Kay. A Three-Dimensional NMR Experiment for the Separation of Aliphatic Carbon Chemical Shifts via the Carbonyl Chemical Shift in 15N, 13C Labeled Proteins. J. Magn. Reson., Ser. B 101, 110-113 (1993). (55.pdf) (DOI)

56.M. Görlach, M. Wittekind, B.T. Farmer II, Lewis E. Kay and L. Mueller. Measurement of 3JHNα Vicinal Coupling Constants in Proteins. J. Magn. Reson., Ser. B 101, 194-197 (1993). (56.pdf) (DOI)

57.Lewis E. Kay, P. Keifer and T. Saarinen. Pure Absorption Gradient Enhanced Heteronuclear Single Quantum Correlation Spectroscopy with Improved Sensitivity. J. Am. Chem. Soc. 114, 10663-10665 (1992). (57.pdf) (57_SI.pdf) (DOI)

58.D.A. Torchia, L.K. Nicholson, H.B.R. Cole and Lewis E. Kay. Heteronuclear NMR Studies of the Molecular Dynamics of Staphylococcal Nuclease. In “Topics in Molecular and Structural Biology Series: NMR of Proteins”. pp 190-219, Eds. G.M. Clore and A.M. Gronenborn; The Macmillan Press Ltd (1993). (58_scan.pdf) (DOI)

59.Lewis E. Kay. A Pulsed-Field Gradient-Enhanced Three-Dimensional NMR Experiment for Correlating 13Cα/β, 13C′, 1Hα Chemical Shifts in Uniformly 13C-Labeled Proteins Dissolved in H2O. J. Am. Chem. Soc. 115, 2055-2057 (1993). (59.pdf) (DOI)

60.Lewis E. Kay, G.-Y. Xu, A.U. Singer, D.R. Muhandiram and J.D. Forman-Kay. A Gradient-Enhanced HCCH-TOCSY Experiment for Recording Side-Chain 1H and 13C Correlations in H2O Samples of Proteins. J. Magn. Reson., Ser. B 101, 333-337 (1993). (60.pdf) (DOI)

61.D.R. Muhandiram, G.Y. Xu and Lewis E. Kay. An Enhanced-Sensitivity Pure Absorption Gradient 4D 15N,13C-Edited NOESY Experiment. J. Biomol. NMR 3, 463-470 (1993). (61.pdf) (DOI)

62.D.R. Muhandiram, N.A. Farrow, G.-Y. Xu, S. H. Smallcombe and Lewis E. Kay. A Gradient 13C NOESY-HSQC Experiment for Recording NOESY Spectra of 13C-Labeled Proteins Dissolved in H2O. J. Magn. Reson., Ser. B 102, 317-321 (1993). (62.pdf) (DOI)

63.T. Yamazaki, J.D. Forman-Kay and Lewis E. Kay. Two-Dimensional NMR Experiments for Correlating 13Cβ-1Hδ/ε Chemical Shifts of Aromatic Residues in 13C-Labeled Proteins via Scalar Couplings. J. Am. Chem. Soc. 115, 11054-11055 (1993). (63.pdf) (DOI)

64.D.R. Muhandiram and Lewis E. Kay. Gradient-Enhanced Triple-Resonance Three-Dimensional NMR Experiments with Improved Sensitivity. J. Magn. Reson., Ser. B 103, 203-216 (1994). (64.pdf) (DOI)

65.S.M. Pascal, D.R. Muhandiram, T. Yamazaki, J.D. Forman-Kay and Lewis E. Kay. Simultaneous Acquisition of 15N- and 13C-Edited NOE Spectra of Proteins Dissolved in H2O. J. Magn. Reson., Ser. B 103, 197-201 (1994). (65.pdf) (DOI)

66.S. Bagby, T.S. Harvey, Lewis E. Kay, S.G. Eagle, S. Inouye and M. Ikura. Unusual Helix-Containing Greek Keys in Development-Specific Ca2+-Binding Protein S. 1H, 15N and 13C Assignments and Secondary Structure Determined with the Use of Multidimensional Double and Triple Resonance Heteronuclear NMR Spectroscopy. Biochemistry 33, 2409-2421 (1994). (66.pdf) (DOI) (pubmed)

67.N.A. Farrow, R. Muhandiram, A.U. Singer, S.M. Pascal, C.M. Kay, G. Gish, S.E. Shoelson, T. Pawson, J.D. Forman-Kay and Lewis E. Kay. Backbone Dynamics of a Free and Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation. Biochemistry 33, 5984-6003 (1994). (67.pdf) (67_SI.pdf) (DOI) (pubmed)

68.T. Yamazaki, D.R. Muhandiram and Lewis E. Kay. NMR Experiments for the Measurement of Carbon Relaxation Properties in Highly Enriched, Uniformly 13C,15N-Labeled Proteins: Application to 13Cα Carbons. J. Am. Chem. Soc. 116, 8266-8278 (1994). (68.pdf) (DOI)

69.Lewis E. Kay, G.Y. Xu and T. Yamazaki. Enhanced-Sensitivity Triple-Resonance Spectroscopy with Minimal H2O Saturation. J. Magn. Reson., Ser. A 109, 129-133 (1994). (69.pdf) (DOI)

70.S.M. Pascal, A.U. Singer, G. Gish, T. Yamazaki, S.E. Shoelson, T. Pawson, Lewis E. Kay and J.D. Forman-Kay. Nuclear Magnetic Structure of an SH2 Domain of Phospholipase C-γ1 Complexed with a High Affinity Binding Peptide. Cell 77, 461-472 (1994). (70.pdf) (DOI) (pubmed)

71.T. Yamazaki, W. Lee, M. Revington, D.L. Mattiello, F.W. Dahlquist, C.H. Arrowsmith and Lewis E. Kay. An HNCA Pulse Scheme for the Backbone Assignment of 15N,13C,2H Labeled Proteins: Application to a 37-kDa Trp Repressor-DNA Complex. J. Am. Chem. Soc. 116, 6464-6465 (1994). (71.pdf) (DOI)

72.N.A. Farrow, O. Zhang, J.D. Forman-Kay and Lewis E. Kay. A Heteronuclear Correlation Experiment for Simultaneous Determination of 15N Longitudinal Decay and Chemical Exchange Rates of Systems in Slow Equilibrium. J. Biomol. NMR 4, 727-734 (1994). (72.pdf) (DOI) (pubmed)

73.W. Lee, M.J. Revington, C.H. Arrowsmith and Lewis E. Kay. A Pulsed Field Gradient Isotope-Filtered 3D 13C HMQC-NOESY Experiment for Extracting Intermolecular NOE Contacts in Molecular Complexes. FEBS Lett. 350, 87-90 (1994). (73.pdf) (DOI) (pubmed)

74.O. Zhang, Lewis E. Kay, J.P. Olivier and J.D. Forman-Kay. Backbone 1H and 15N Resonance Assignments of the N-Terminal SH3 Domain of Drk in Folded and Unfolded States using Enhanced-Sensitivity Pulsed Field Gradient NMR Techniques. J. Biomol. NMR 4, 845-858 (1994). (74.pdf) (DOI) (pubmed)

75.T. Yamazaki, W. Lee, C.H. Arrowsmith, D.R. Muhandiram and Lewis E. Kay. A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity. J. Am. Chem. Soc. 116, 11655-11666 (1994). (75.pdf) (DOI)

76.C.H. Arrowsmith, W. Lee, M. Revington, T. Yamazaki and Lewis E. Kay. Toward the Solution Structure of Large (> 30 kDa) Proteins and Macromolecular Complexes. In “Techniques in Protein Chemistry” Ed. J.W. Crabb; Academic Press, vol 6, pp 503-510 (1995). (76.pdf) (DOI)

77.N.A. Farrow, O. Zhang, J.D. Forman-Kay and Lewis E. Kay. Comparison of the Backbone Dynamics of a Folded and an Unfolded SH3 Domain Existing in Equilibrium in Aqueous Buffer. Biochemistry 34, 868-878 (1995). (77.pdf) (DOI) (pubmed)

78.T. Yamazaki, S.M. Pascal, A.U. Singer, J.D. Forman-Kay and Lewis E. Kay. NMR Pulse Schemes for the Sequence-Specific Assignment of Arginine Guanidino 15N and 1H Chemical Shifts in Proteins. J. Am. Chem. Soc. 117, 3556-3564 (1995). (78.pdf) (DOI)

79.M.K. Rosen, T. Yamazaki, G.D. Gish, C.M. Kay, T. Pawson and Lewis E. Kay. Direct Demonstration of an Intramolecular SH2-Phosphotyrosine Interaction in the Crk Protein. Nature 374, 477-479 (1995). (79.pdf) (DOI) (pubmed)

80.N.A. Farrow, O. Zhang, A. Szabo, D.A. Torchia and Lewis E. Kay. Spectral Density Function Mapping Using 15N Relaxation Data Exclusively. J. Biomol. NMR 6, 153-162 (1995). (80.pdf) (DOI) (pubmed)

81.G.-Y. Xu, E. Ong, N.R. Gilkes, D.G. Kilburn, D.R. Muhandiram, M. Harris-Brandts, J.P. Carver, Lewis E. Kay and T.S. Harvey. Solution Structure of a Cellulose-Binding Domain from Cellulomonas fimi by Nuclear Magnetic Resonance Spectroscopy. Biochemistry 34, 6993-7009 (1995). (81.pdf) (81_SI.tar) (DOI) (pubmed)

82.Lewis. E. Kay. Pulsed Field Gradient Multi-Dimensional NMR Methods for the Study of Protein Structure and Dynamics in Solution. Prog. Biophys. Molec. Biol. 63, 277-299 (1995). (82.pdf) (DOI) (pubmed)

83.D.R. Muhandiram, T. Yamazaki, B.D. Sykes and Lewis E. Kay. Measurement of 2H T1 and T Relaxation Times in Uniformly 13C-Labeled and Fractionally 2H-Labeled Proteins in Solution. J. Am. Chem. Soc. 117, 11536-11544 (1995). (83.pdf) (DOI)

84.Lewis E. Kay. Field Gradient Techniques in NMR Spectroscopy. Curr. Opin. Struct. Biol. 5, 674-681 (1995). (84.pdf) (DOI) (pubmed)

85.M.M. McEvoy, H. Zhou, A.F. Roth, D.F. Lowry, T.B. Morrison, Lewis E. Kay and F.W. Dahlquist. Nuclear Magnetic Resonance Assignments and Global Fold of a CheY-Binding Domain in CheA, the Chemotaxis-Specific Kinase of Escherichia coli. Biochemistry 34, 13871-13880 (1995). (85.pdf) (85_SI.tar) (DOI) (pubmed)

86.S.M. Pascal, T. Yamazaki, A.U. Singer, Lewis E. Kay and J.D. Forman-Kay. Structural and Dynamic Characterization of the Phosphotyrosine Binding Region of a Src Homology 2 Domain-Phoshopeptide Complex by NMR Relaxation, Proton Exchange, and Chemical Shift Approaches. Biochemistry 34, 11353-11362 (1995). (86.pdf) (86_SI.tar) (DOI) (pubmed)

87.S.M. Pascal, A.U. Singer, T. Yamazaki, Lewis E. Kay and J.D. Forman-Kay. Structural and Dynamic Characterization of an SH2 Domain-Phosphopeptide Complex by NMR Approaches. Biochem. Soc. Trans. 23, 729-733 (1995). (87.pdf) (DOI)

88.L.K. Nicholson, Lewis E. Kay and D.A. Torchia. Protein Dynamics as Studied by Solution NMR Techniques (Chapter 5). In “NMR Spectroscopy and Its Applications to Biomedical Research”. Ed. S.K. Sarkar; Elsevier, Amsterdam (1996). (88.pdf) (DOI)

89.D.R. Muhandiram and Lewis E. Kay. Three Dimensional HMQC-NOESY, NOESY-HMQC and NOESY-HSQC. In “Encyclopedia of Nuclear Magnetic Resonance”. Vol 7, pp 4733-4744, Eds. D.M. Grant, R.K. Harris; John Wiley and Sons, Baffins Lane, Chichester, West Sussex (1996). Epub 15 Mar 2007. (89_scan.pdf) (89_epub.pdf) (DOI_epub)

90.J.D. Forman-Kay, S.M. Pascal, A.U. Singer, T. Yamazaki, O. Zhang, N.A. Farrow and Lewis E. Kay. Structural, Dynamic and Folding Studies of SH2 and SH3 Domains. In “NMR as a Structural Tool for Macromolecules: Current Status and Future Directions”. pp 35-47, Eds. B.D.N. Rao, M.D. Kemple; Plenum, New York (1996). (90_scan.pdf) (DOI)

91.Lewis E. Kay, D.R Muhandiram, N.A. Farrow, Y. Aubin and J.D. Forman-Kay. Correlation between Dynamics and High Affinity Binding in an SH2 Domain Interaction. Biochemistry (Accelerated) 35, 361-368 (1996). (91.pdf) (91_SI.pdf) (DOI) (pubmed)

92.D. Yang and Lewis E. Kay. The Effects of Cross Correlation and Cross Relaxation on the Measurement of Deuterium T1 and T Relaxation Times in 13CH2D Spin Systems. J. Magn. Reson., Ser. B 110, 213-218 (1996). (92.pdf) (DOI)

93.K.A. Williams, N.A. Farrow, C.M. Deber and Lewis E. Kay. Structure and Dynamics of Bacteriophage IKe Major Coat Protein in MPG Micelles by Solution NMR. Biochemistry 35, 5145-5157 (1996). (93.pdf) (93_SI.pdf) (DOI) (pubmed)

94.M.M. McEvoy, D.R. Muhandiram, Lewis E. Kay and F.W. Dahlquist. Structure and Dynamics of a CheY-Binding Domain of the Chemotaxis Kinase CheA Determined by Nuclear Magnetic Resonance Spectroscopy. Biochemistry 35, 5633-5640 (1996). (94.pdf) (94_SI.pdf) (DOI) (pubmed)

95.M. Anafi, M.K. Rosen, G.D. Gish, Lewis E. Kay and T. Pawson. A Potential SH3 Domain-Binding Site in the Crk SH2 Domain. J. Biol. Chem. 271, 21365-21374 (1996). (95.pdf) (DOI) (pubmed)

96.X. Shan, K.H. Gardner, D.R. Muhandiram, N.S. Rao, C.H. Arrowsmith and Lewis E. Kay. Assignment of 15N, 13Cα, 13Cβ and HN Resonances in an 15N,13C,2H Labeled 64 kDa Trp Repressor-Operator Complex Using Triple-Resonance NMR Spectroscopy and 2H-Decoupling. J. Am. Chem. Soc. 118, 6570-6579 (1996). (96.pdf) (DOI)

97.D. Yang and Lewis E. Kay. Contributions to Conformational Entropy Arising from Bond Vector Fluctuations Measured from NMR Derived Order Parameter: Application to Protein Folding. J. Mol. Biol. 263, 369-382 (1996). (97.pdf) (DOI) (pubmed)

98.G.-Yi Xu, J. Hong, T. McDonagh, M. Stahl, Lewis E. Kay, J. Seehra and D.A. Cumming. Complete 1H, 15N and 13C Assignments, Secondary Structure, and Topology of Recombinant Human Interleukin-6. J. Biomol. NMR 8, 123-135 (1996). (98.pdf) (DOI) (pubmed)

99.M.K. Rosen, K.H. Gardner, R.C. Willis, W.E. Parris, T. Pawson and Lewis E. Kay. Selective Methyl Protonation of Perdeuterated Proteins. J. Mol. Biol. 263, 627-636 (1996). (99.pdf) (DOI) (pubmed)

100.K.H. Gardner, R. Konrat, M.K. Rosen and Lewis E. Kay, An (H)C(CO)NH-TOCSY Pulse Scheme for Sequential Assignment of Protonated Methyl Groups in Otherwise Deuterated 15N,13C-Labeled Proteins. J. Biomol. NMR 8, 351-356 (1996). (100.pdf) (DOI) (pubmed)

101.J.L. Battiste, H. Mao, N.S. Rao, R. Tan, D.R. Muhandiram, Lewis E. Kay, A.D. Frankel and J.R. Williamson. α-Helix-RNA Major Groove Recognition in an HIV-1 Peptide-RRE RNA Complex. Science 273, 1547-1551 (1996). (101.pdf) (DOI) (pubmed)

102.O. Zhang, J.D. Forman-Kay, D. Shortle and Lewis E. Kay. Triple-Resonance NOESY-Based Experiments with Improved Spectral Resolution: Applications to Structural Characterization of Unfolded, Partially Folded and Folded Proteins. J. Biomol. NMR 9, 181-200 (1996). (102.pdf) (DOI) (pubmed)

103.G.-Yi Xu, H.-A. Yu, J. Hong, M. Stahl, T. McDonagh, Lewis E. Kay and D.A. Cumming. Solution Structure of Recombinant Human Interleukin-6. J. Mol. Biol. 268, 468-481 (1997). (103.pdf) (DOI) (pubmed)

104.K.H. Gardner, M.K. Rosen and Lewis E. Kay. Global Folds of Highly Deuterated, Methyl-Protonated Proteins by Multidimensional NMR. Biochemistry 36, 1389-1401 (1997). (104.pdf) (DOI) (pubmed)

105.N.A. Farrow, O. Zhang, J.D. Forman-Kay and Lewis E. Kay. Characterization of the Backbone Dynamics of Folded and Denatured States of an SH3 Domain. Biochemistry 36, 2390-2402 (1997). (105.pdf) (105_SI.pdf) (DOI) (pubmed)

106.N.S. Rao, P. Legault, D.R. Muhandiram, J. Greenblatt, J.L. Battiste, J.R. Williamson and Lewis E. Kay. NMR Pulse Schemes for the Sequential Assignment of Arginine Sidechain Hε Protons. J. Magn. Reson., Ser. B 113, 272-276 (1996). (106.pdf) (DOI) (pubmed)

107.R. Konrat, D.R. Muhandiram, N.A. Farrow and Lewis E. Kay. Pulse Schemes for the Measurement of 3JC′Cγ and 3JNCγ Scalar Couplings in 15N,13C Uniformly Labeled Proteins. J. Biomol. NMR 9, 409-422 (1997). (107.pdf) (DOI) (pubmed)

108.Lewis E. Kay. NMR Methods for the Study of Protein Structure and Dynamics. Biochem. Cell Biol. 75, 1-15 (1997). (108.pdf) (DOI) (pubmed)

109.C. Zwahlen, P. Legault, S.J.F. Vincent, J. Greenblatt, R. Konrat and Lewis E. Kay. Methods for Measurement of Intermolecular NOEs by Multinuclear NMR Spectroscopy: Application to a Bacteriophage λ N-peptide/boxB RNA Complex. J. Am. Chem. Soc. 119, 6711-6721 (1997). (109.pdf) (DOI)

110.L.P. McIntosh, E. Brun and Lewis E. Kay. Stereospecific Assignment of the NH2 Resonances from the Primary Amides of Asparagine and Glutamine Side Chains in Isotopically Labeled Proteins. J. Biomol. NMR 9, 306-312 (1997). (110.pdf) (DOI) (pubmed)

111.K.H. Gardner and Lewis E. Kay. Production and Incorporation of 15N, 13C, 2H (1H-δ1 methyl) Isoleucine into Proteins for Multidimensional NMR Studies. J. Am. Chem. Soc. 119, 7599-7600 (1997). (111.pdf) (111_SI.pdf) (DOI)

112.S. Li, Z. Songyang, S.J.F. Vincent, C. Zwahlen, S. Wiley, L. Cantley, Lewis E. Kay, J.D. Forman-Kay and T. Pawson. High-Affinity Binding of the Drosophila Numb Phosphotyrosine-Binding Domain to Peptides Containing a Gly-Pro-(p)Tyr Motif. Proc. Natl. Acad. USA 94, 7204-7209 (1997). (112.pdf) (DOI) (pubmed)

113.O. Zhang, Lewis E. Kay, D. Shortle and J.D. Forman-Kay. Comprehensive NOE Characterization of a Partially Folded Large Fragment of Staphylococcal Nuclease, Δ131Δ, Using NMR Methods with Improved Resolution. J. Mol. Biol. 272, 9-20 (1997). (113.pdf) (DOI) (pubmed)

114.L. Spyracopoulos, S.M. Gagné, W. Gronwald, Lewis E. Kay and B.D. Sykes. NMR Studies of Protein Sidechain Dynamics: Examples from Antifreeze and Calcium-regulatory Proteins. In “Proceedings for the International School of Structural Biology and Magnetic Resonance, 3rd Course on Protein Dynamics, Function and Design”. NATO ASI Series, vol 301, pp 147-162, Eds. O. Jardetzky, J.F Lefèvre, R.E. Holbrook; Plenum Press, NY (1998). (114_scan.pdf) (DOI)

115.D. Yang, Y.-K. Mok, J.D. Forman-Kay, N.A. Farrow and Lewis E. Kay. Contributions to Protein Entropy and Heat Capacity from Bond Vector Motions Measured by NMR Spin Relaxation. J. Mol. Biol. 272, 790-804 (1997). (115.pdf) (DOI) (pubmed)

116.Lewis E. Kay and K.H. Gardner. Solution NMR Spectroscopy Beyond 25 kDa. Curr. Opin. Struct. Biol. 7, 722-731 (1997). (116.pdf) (DOI) (pubmed)

117.D.R. Muhandiram, P.E. Johnson, D. Yang, O. Zhang, L.P. McIntosh and Lewis E. Kay. Specific 15N, NH Correlations for Residues in 15N, 13C and Fractionally Deuterated Proteins that Immediately Follow Methyl-Containing Amino Acids. J. Biomol. NMR 10, 283-288 (1997). (117.pdf) (DOI) (pubmed)

118.D. Yang, R. Konrat and Lewis E. Kay. A Multidimensional NMR Experiment for Measurement of the Protein Dihedral angle ψ Based on Cross-Correlated Relaxation Between 1Hα-13Cα Dipolar and 13C′ (Carbonyl) Chemical Shift Anisotropy Mechanisms. J. Am. Chem. Soc. 119, 11938-11940 (1997). (118.pdf) (118_SI.pdf) (DOI)

119.Lewis E. Kay. The Development of NMR Methods to Study Protein Structure and Dynamics. In “New Methods for the Study of Biomolecular Complexes”. NATO ASI Series, vol 510, pp 285-293, Eds. W. Ens, K.G. Standing, I.V. Chernushevich; Kluwer Academic Publishers (1998). (119_scan.pdf) (DOI)

120.K.H. Gardner and Lewis E. Kay. The Use of 2H, 13C, 15N Multidimensional NMR to Study the Structure and Dynamics of Proteins. Annu. Rev. Biophys. Biomol. Struct. 27, 357-406 (1998). (120.pdf) (DOI) (pubmed)

121.C. Zwahlen, S.J.F. Vincent and Lewis E. Kay. Analytical Description of the Effect of Adiabatic Pulses in IS, I2S and I3S Spin Systems. J. Magn. Reson. 130, 169-175 (1998). (121.pdf) (DOI) (pubmed)

122.X. Shan, K.H. Gardner, D.R. Muhandiram, Lewis E. Kay and C.H. Arrowsmith. Subunit-Specific Backbone NMR Assignments of a 64 kDa trp Repressor/DNA Complex: A Role for N-Terminal Residues in Tandem Binding. J. Biomol. NMR 11, 307-318 (1998). (122.pdf) (DOI) (pubmed)

123.Lewis E. Kay, D.R. Muhandiram, G. Wolf, S.E. Shoelson and J.D. Forman-Kay. Correlation Between Binding and Dynamics at SH2 Domain Interfaces. Nat. Struct. Biol. 5, 156-163 (1998). (123.pdf) (DOI) (pubmed)

124.D. Yang, A. Mittermaier, Y.-K. Mok and Lewis E. Kay. A Study of Protein Side-Chain Dynamics from New 2H Auto-Correlation and 13C Cross-Correlation NMR Spectroscopy: Application to the N-terminal SH3 Domain of Drk. J. Mol. Biol. 276, 939-954 (1998). (124.pdf) (DOI) (pubmed)

125.J. Mogridge, P. Legault, J. Li, M.D. Van Oene, Lewis E. Kay and J. Greenblatt. Independent Ligand-Induced Folding of the RNA-Binding Domain and Two Functionally Distinct Antitermination Regions in the Phage λ N Protein. Mol. Cell 1, 265-275 (1998). (125.pdf) (DOI) (pubmed)

126.D. Yang, K.H. Gardner and Lewis E. Kay. A Sensitive Pulse Scheme for Measuring the Backbone Dihedral Angle ψ Based on Cross-Correlation Between 13Cα-1Hα Dipolar and Carbonyl Chemical Shift Anisotropy Relaxation Interactions. J. Biomol. NMR 11, 213-220 (1998). (126.pdf) (DOI) (pubmed)

127.S. Gagné, S. Tsuda, L. Spyracopoulos, Lewis E. Kay and B.D. Sykes. Backbone and Methyl Dynamics of the Regulatory Domain of Troponin C: Anisotropic Rotational Diffusion and Contribution of Conformational Entropy to Calcium Affinity. J. Mol. Biol. 278, 667-686 (1998). (127.pdf) (127_SI.tar) (DOI) (pubmed)

128.C. Zwahlen, S.J.F. Vincent, K.H. Gardner and Lewis E. Kay. Significantly Improved Resolution for NOE Correlations from Valine and Isoleucine (Cγ2) Methyl Groups in 15N,13C and 15N-,13C,2H-Labeled Proteins. J. Am. Chem. Soc. 120, 4825-4831 (1998). (128.pdf) (DOI)

129.P. Legault, J. Li, J. Mogridge, Lewis E. Kay and J. Greenblatt. NMR Structure of the Bacteriophage λ N-Peptide/boxB RNA Complex: Recognition of a GNRA Fold by an Arginine-Rich Motif. Cell 93, 289-299 (1998). (129.pdf) (DOI) (pubmed)

130.D. Yang, J.R. Tolman, N.K. Goto and Lewis E. Kay. An HNCO-based Pulse Scheme for the Measurement of 13Cα-1Hα One-Bond Dipolar Couplings in 15N, 13C Labeled Proteins. J. Biomol. NMR 12, 325-332 (1998). (130.pdf) (DOI) (pubmed)

131a.Lewis E. Kay. Protein Dynamics from NMR. Nat. Struct. Biol. 5, 513-517 (1998). (131a.pdf) (DOI) (pubmed)
131b.Lewis E. Kay. Protein Dynamics from NMR. Biochem. Cell Biol. 76, 145-152 (1998). (131b.pdf) (DOI) (pubmed)

132.C. Zwahlen, K.H. Gardner, S.P. Sarma, D.A. Horita, R.A. Byrd and Lewis E. Kay. An NMR Experiment for Measuring Methyl-Methyl NOEs in 13C-Labeled Proteins with High Resolution. J. Am. Chem. Soc. 120, 7617-7625 (1998). (132.pdf) (DOI)

133.S.-C. Li, C. Zwahlen, S.J.F. Vincent, C.J. McGlade, Lewis E. Kay, T. Pawson and J.D. Forman-Kay. Structure of a Numb PTB Domain-Peptide Complex Suggests a Basis for Diverse Binding Specificity. Nat. Struct. Biol. 5, 1075-1083 (1998). (133.pdf) (DOI) (pubmed)

134.V. Kanelis, N.A. Farrow, Lewis E. Kay, D. Rotin and J.D. Forman-Kay. NMR Studies of Tandem WW Domains of Nedd4 in Complex with a PY Motif-Containing Region of the Epithelial Sodium Channel. Biochem. Cell Biol. 76, 341-350 (1998). (134.pdf) (DOI) (pubmed)

135.K.H. Gardner, X. Zhang, K. Gehring and Lewis E. Kay. Solution NMR Studies of a 42 kDa Escherichia coli Maltose Binding Protein/β-Cyclodextrin Complex: Chemical Shift Assignments and Analysis. J. Am. Chem. Soc. 120, 11738-11748 (1998). (135.pdf) (135_SI.pdf) (DOI)

136.J. Greenblatt, T.F. Mah, P. Legault, J. Morgridge, J. Li and Lewis E. Kay. Structure and Mechanism in Transcriptional Antitermination by the Bacteriophage λ N Protein. Cold Spring Harb. Symp. Quant. Biol. 63, 327-336 (1998). (136_scan.pdf) (DOI) (pubmed)

137.D. Yang and Lewis E. Kay. Determination of the Protein Backbone Dihedral Angle ψ From a Combination of NMR-Derived Cross-Correlation Spin Relaxation Rates. J. Am. Chem. Soc. 120, 9880-9887 (1998). (137.pdf) (137_SI.pdf) (DOI)

138.D. Liu, R. Ishima, K.I. Tong, S. Bagby, T. Kokubo, D.R. Muhandiram, Lewis E. Kay, Y. Nakatani and M. Ikura. Solution Structure of a TBP-TAFII230 Complex: Protein Mimicry of the Minor Groove Surface of the TATA Box Unwound by TBP. Cell 94, 573-583 (1998). (138.pdf) (DOI) (pubmed)

139.K.H. Gardner and Lewis E. Kay. Multidimensional 2H-Based NMR Methods for Resonance Assignment, Structure Determination, and the Study of Protein Dynamics. In “Modern Techniques in Protein NMR. Biological Magnetic Resonance. Vol. 16, pp 27-74; Eds. N.R. Krishna, L.J. Berliner, Kluwer/Plenum, New York (1998). (139_scan.pdf) (DOI)

140.D. Yang and Lewis E. Kay. Improved 1HN-Detected Triple Resonance TROSY-Based Experiments. J. Biomol. NMR 13, 3-10 (1999). (140.pdf) (DOI) (pubmed)

141.A. Mittermaier, Lewis E. Kay and J.D. Forman-Kay. Analysis of Deuterium Relaxation-Derived Methyl Axis Order Parameters and Correlation with Local Structure. J. Biomol. NMR 13, 181-185 (1999). (141.pdf) (DOI) (pubmed)

142.D. Yang and Lewis E. Kay. TROSY Triple-Resonance Four-Dimensional NMR Spectroscopy of a 46 ns Tumbling Protein. J. Am. Chem. Soc. 121, 2571-2575 (1999). (142.pdf) (142_SI.pdf) (DOI)

143.N.K. Goto, K.H. Gardner, G.A. Mueller, R.C. Willis and Lewis E. Kay. A Robust and Cost-Effective Method for the Production of Val, Leu, Ile (δ1) Methyl Protonated 15N-, 13C-, 2H-Labeled Proteins. J. Biomol. NMR 13, 369-374 (1999). (143.pdf) (143_SI.pdf) (DOI) (pubmed)

144.D. Yang, Y.-K. Mok, D.R. Muhandiram, J.D. Forman-Kay and Lewis E. Kay. 1H-13C Dipole-Dipole Cross-Correlated Spin Relaxation as a Probe of Dynamics in Unfolded Proteins: Application to the DrkN SH3 Domain. J. Am. Chem. Soc. 121, 3555-3556 (1999). (144.pdf) (144_SI.pdf) (DOI)

145.Y.-K. Mok, C.M. Kay, Lewis E. Kay and J.D. Forman-Kay. NOE Data Demonstrating a Compact Unfolded State for an SH3 Domain Under Non-Denaturing Conditions. J. Mol. Biol. 289, 619-638 (1999). (145.pdf) (DOI) (pubmed)

146.D. Yang and Lewis E. Kay. Improved Lineshape and Sensitivity in the HNCO-Family of Triple Resonance Experiments. J. Biomol. NMR 14, 273-276 (1999). (146.pdf) (DOI)

147.D. Yang, R.A. Venters, G.A. Mueller, W.Y. Choy and Lewis E. Kay. TROSY-Based HNCO Pulse Sequences for the Measurement of 1HN-15N, 15N-13CO, 1HN-13CO, 13CO-13Cα and 1HN-13Cα Dipolar Couplings in 15N, 13C, 2H-Labeled Proteins. J. Biomol. NMR 14, 333-343 (1999). (147.pdf) (DOI)

148.A. Mittermaier, L. Varani, D.R. Muhandiram, Lewis E. Kay and G. Varani. Changes in Side-Chain and Backbone Dynamics Identify Determinants of Specificity in RNA Recognition by Human U1A Protein. J. Mol. Biol. 294, 967-979 (1999). (148.pdf) (DOI) (pubmed)

149.A. Mittermaier and Lewis E. Kay. Measurement of Methyl 2H Quadrupolar Couplings in Oriented Proteins. How Uniform is the Quadrupolar Coupling Constant? J. Am. Chem. Soc. 121, 10608-10613 (1999). (149.pdf) (DOI)

150.R. Konrat, D. Yang and Lewis E. Kay. A 4D TROSY-Based Scheme for Correlating 1HNi, 15Ni, 13Cαi,13C′i-1 Chemical Shifts in High Molecular Weight, 15N, 13C, 2H Labeled Proteins. J. Biomol. NMR 15, 967-979 (1999). (150.pdf) (DOI) (pubmed)

151.S.-C. Li, G. Gish, D. Yang, A.J. Coffey, J.D. Forman-Kay, I. Ernberg, Lewis E. Kay and T. Pawson. Novel Mode of Ligand Binding by the SH2 Domain of the Human XLP Disease Gene Product SAP/SH2D1A. Curr. Biol. 9, 1355-1362 (1999). (151.pdf) (DOI) (pubmed)

152.N.R. Skrynnikov, N.K. Goto, D. Yang, W.-Y. Choy, J.R. Tolman, G.A. Mueller and Lewis E. Kay. Orienting Domains in Proteins Using Dipolar Couplings Measured by Liquid-State NMR: Differences in Solution and Crystal Forms of Maltodextrin Binding Protein Loaded with β-Cyclodextrin. J. Mol. Biol. 295, 1265-1273 (2000). (152.pdf) (DOI) (pubmed)

153.C. Zwahlen, S.-C. Li, Lewis E. Kay, T. Pawson and J.D. Forman-Kay. Multiple Modes of Peptide Recognition by the PTB Domain of the Cell Fate Determinant Numb. EMBO J. 19, 1505-1515 (2000). (153.pdf) (DOI)

154.T. Kortemme, M.J.S. Kelly, Lewis E. Kay, J.D. Forman-Kay and L. Serrano. Similarities Between the Spectrin SH3 Domain Denatured State Resembles its Folding Transition State. J. Mol. Biol. 297, 1217-1229 (2000). (154.pdf) (DOI) (pubmed)

155.L. Varani, S.I. Gunderson, I.W. Mattaj, Lewis E. Kay, D. Neuhaus and G. Varani. The NMR Structure of the 38 kDa U1A Protein-PIE RNA Complex Reveals the Basis of Cooperativity in Regulation of Polyadenylation by Human U1A Protein. Nat. Struct. Biol. 7, 329-335 (2000). (155.pdf) (DOI) (pubmed)

156.V. Kanelis, L. Donaldson, D.R. Muhandiram, D. Rotin, J.D. Forman-Kay and Lewis E. Kay. Sequential Assignment of Proline-Rich Regions in Proteins: Application to Modular Binding Domain Complexes. J. Biomol. NMR 16, 253-259 (2000). (156.pdf) (DOI) (pubmed)

157.N.R. Skrynnikov, R. Konrat, D.R. Muhandiram and Lewis E. Kay. Relative Orientation of Peptide Planes is Reflected in Carbonyl-Carbonyl Chemical Shift Anisotropy Cross-Correlated Spin Relaxation. J. Am. Chem. Soc 122, 7059-7071 (2000). (157.pdf) (157_SI.pdf) (DOI)

158.G.A. Mueller, W.Y. Choy, D. Yang, J.D. Forman-Kay, R.A. Venters and Lewis E. Kay. Global Folds of Proteins with Low Densities of NOEs Using Residual Dipolar Couplings: Application to the 370 Residue Maltodextrin-Binding Proteins. J. Mol. Biol. 300, 197-212 (2000). (158.pdf) (DOI) (pubmed)

159.F.A.A. Mulder, A. Ayed, D. Yang, C.H. Arrowsmith and Lewis E. Kay. Assignment of 1HN, 15N, 13Cα and 13Cβ Resonances in a 67 kDa p53 Dimer using 4D-TROSY NMR Spectroscopy. J. Biomol. NMR 18, 173-176 (2000). (159.pdf) (159_SI.pdf) (DOI) (pubmed)

160.N.K. Goto and Lewis E. Kay. New Developments in Isotope Labeling Strategies for Protein Solution NMR Spectroscopy. Curr. Opin. Struct. Biol. 10, 585-592 (2000). (160.pdf) (DOI) (pubmed)

161.F.A.A. Mulder, B. Hon, D.R. Muhandiram, F.W. Dahlquist and Lewis E. Kay. Flexibility and Ligand Exchange in a Buried Cavity Mutant of T4 Lysozyme Studied by Multinuclear NMR. Biochemistry 39, 12614-12622 (2000). (161.pdf) (DOI) (pubmed)

162.G.A. Mueller, W.Y. Choy, N.R. Skrynnikov and Lewis E. Kay. A Method for Incorporating Dipolar Couplings into Structure Calculations in Cases of (Near) Axial Symmetry of Alignment. J. Biomol. NMR 18, 183-188 (2000). (162.pdf) (DOI) (pubmed)

163.N.R. Skrynnikov and Lewis E. Kay. Assessment of Molecular Structure Using Frame-Independent Orientational Restraints Derived from Residual Dipolar Couplings. J. Biomol. NMR 18, 239-252 (2000). (163.pdf) (DOI) (pubmed)

164.Lewis E. Kay. NMR Methods for the Study of High Molecular Weight Proteins: A Study Involving a Complex of Maltose Binding Protein and β-cyclodextrin. Methods Enzymol. 339, 174-203 (2001). (164.pdf) (DOI) (pubmed)

165.J.R. Tolman, H.M. Al-Hashimi, Lewis E. Kay and J.H. Prestegard. Structural and Dynamic Analysis of Residual Dipolar Coupling Data for Proteins. J. Am. Chem. Soc. 123, 1416-1424 (2001). (165.pdf) (165_SI.pdf) (DOI) (pubmed)

166.F.A.A. Mulder, N.R. Skrynnikov, B. Hon, F.W. Dahlquist and Lewis E. Kay. Measurement of Slow (μs-ms) Timescale Dynamics in Protein Side Chains by 15N Relaxation Dispersion NMR Spectroscopy: Application to Asn and Gln Residues in a Cavity Mutant of T4 Lysozyme. J. Am. Chem. Soc. 123, 967-975 (2001). (166.pdf) (DOI) (pubmed)

167.J. Evenäs, A. Mittermaier, D. Yang and Lewis E. Kay. Measurement of 13Cα-13Cβ Dipolar Couplings in 15N,13C,2H-Labeled Proteins: Application to Domain Orientation in Maltose Binding Protein. J. Am. Chem. Soc. 123, 2858-2864 (2001). (167.pdf) (DOI) (pubmed)

168.N.R. Skrynnikov, F.A.A. Mulder, B. Hon, F.W. Dahlquist and Lewis E. Kay. Probing Slow Timescale Dynamics at Methyl-Containing Side Chains in Proteins by Relaxation Dispersion NMR Measurements: Application to Methionine Residues in a Cavity Mutant of T4 Lysozyme. J. Am. Chem. Soc. 123, 4556-4566 (2001). (168.pdf) (DOI) (pubmed)

169.N.K. Goto, N.R. Skrynnikov, F.W. Dahlquist and Lewis E. Kay. What is the Average Conformation of T4 Lysozyme in Solution? A Domain Orientation Study Using Dipolar Couplings Measured by Solution NMR. J. Mol. Biol. 308, 745-764 (2001). (169.pdf) (DOI) (pubmed)

170.P.M. Hwang, N.R. Skrynnikov and Lewis E. Kay. Domain Orientation in β-Cyclodextrin-Loaded Maltose Binding Protein: Diffusion Anisotropy Measurements Confirm the Results of a Dipolar Coupling Study. J. Biomol. NMR 20, 83-88 (2001). (170.pdf) (DOI) (pubmed)

171.J. Evenäs, V. Tugarinov, N.R. Skrynnikov, N.K. Goto, R. Muhandiram and Lewis E. Kay. Ligand-Induced Structural Changes to Maltodextrin-Binding Protein as Studied by Solution NMR Spectroscopy. J. Mol. Biol. 309, 961-974 (2001). (171.pdf) (DOI) (pubmed)

172.A. Mittermaier and Lewis E. Kay. χ1 Torsion Angle Dynamics in Proteins from Dipolar Couplings. J. Am. Chem. Soc. 123, 6892-6903 (2001). Epub 19 Jun 2001. (172.pdf) (172_SI.pdf) (DOI) (pubmed)

173.W.-Y. Choy, M. Tollinger, G.A. Mueller and Lewis E. Kay. Direct Structure Refinement of High Molecular Weight Proteins Against Residual Dipolar Couplings and Carbonyl Chemical Shift Changes Upon Alignment: An Application of Maltose Binding Protein. J. Biomol. NMR 21, 31-40 (2001). (173.pdf) (DOI) (pubmed)

174.A. Ayed, F.A.A. Mulder, G.-S. Yi, Y. Lu, Lewis E. Kay and C. H. Arrowsmith. Latent and Active p53 are Identical in Conformation. Nat. Struct. Biol. 8, 756-760 (2001). (174.pdf) (DOI) (pubmed)

175.L.W. Donaldson, N.R. Skrynnikov, W.-Y. Choy, D.R. Muhandiram, B. Sarkar, J D. Forman-Kay and Lewis E. Kay. Structural Characterization of Proteins with an Attached ATCUN Motif by Paramagnetic Relaxation Enhancement NMR Spectroscopy. J. Am. Chem. Soc. 123, 9843-9847 (2001). Epub 15 Sep 2001. (175.pdf) (175_SI.pdf) (DOI) (pubmed)

176.Lewis E. Kay and G.A. Petsko. Editorial Overview: Biophysical Methods. Curr. Opin. Struct. Biol. 11, 513-515 (2001). Epub 5 Oct 2001. (176.pdf) (DOI)

177.M. Tollinger, N.R. Skrynnikov, F.A.A. Mulder, J.D. Forman-Kay and Lewis E. Kay. Slow Dynamics in Folded and Unfolded States of an SH3 Domain. J. Am. Chem. Soc. 123, 11341-11352 (2001). Epub 26 Oct 2001. (177.pdf) (177_SI.pdf) (DOI) (pubmed)

178.F.A.A. Mulder, A. Mittermaier, B. Hon, F.W. Dahlquist and Lewis E. Kay. Studying Excited States of Proteins by Relaxation Dispersion NMR Spectroscopy. Nat. Struct. Biol. 8, 932-935 (2001). (178.pdf) (DOI) (pubmed)

179.F.A.A. Mulder, B. Hon, A. Mittermaier, F.W. Dahlquist and Lewis E. Kay. Slow Internal Dynamics in Proteins: Application of NMR Relaxation Dispersion Spectroscopy to Methyl Groups in a Cavity Mutant of T4 Lysozyme. J. Am. Chem. Soc. 124, 1443-1451 (2002). Epub 24 Jan 2002. (179.pdf) (DOI) (pubmed)

180.P.M. Hwang, C. Li, M. Morra, J. Lillywhite, D.R. Muhandiram, F. Gertler, C. Terhorst, Lewis E. Kay, T. Pawson, J. D. Forman-Kay and S-C. Li. A ‘Three-Pronged’ Binding Mechanism for the SAP/SH2D1A SH2 Domain: Structural Basis and Relevance to the XLP Syndrome. EMBO J. 21, 314-323 (2002). (180.pdf) (DOI) (pubmed)

181.V. Kanelis, J.D. Forman-Kay and Lewis E. Kay. Multidimensional NMR Methods for Protein Structure Determination. IUBMB Life 52, 291-302 (2002). (181.pdf) (DOI) (pubmed)

182.W.-Y. Choy, F.A.A. Mulder, K.A. Crowhurst, D.R. Muhandiram, I.S. Millet, S. Doniach, J.D. Forman-Kay and Lewis E. Kay. Distribution of Molecular Size Within an Unfolded State Ensemble Using Small-Angle X-ray Scattering and Pulsed Field Gradient NMR Techniques. J. Mol. Biol. 316, 101-112 (2002). Epub 25 May 2002. (182.pdf) (DOI) (pubmed)

183.O. Millet, D.R. Muhandiram, N.R. Skrynnikov and Lewis E. Kay. Deuterium Spin Probes of Side-Chain Dynamics in Proteins. 1. Measurement of Five Relaxation Rates per Deuteron in 13C-Labeled and Fractionally 2H-Enriched Proteins in Solution. J. Am. Chem. Soc. 124, 6439-6448 (2002). Epub 11 May 2002. (183.pdf) (183_SI.pdf) (DOI) (pubmed)

184.N.R. Skrynnikov, O. Millet and Lewis E. Kay. Deuterium Spin Probes of Side-Chain Dynamics in Proteins. 2. Spectral Density Mapping and Identification of Nanosecond Time-Scale Side-Chain motions. J. Am. Chem. Soc. 124, 6449-6460 (2002). Epub 11 May 2002. (184.pdf) (184_SI.pdf) (DOI) (pubmed)

185.M. Tollinger, J.D. Forman-Kay and Lewis E. Kay. Measurement of Side-Chain Carboxyl pKa Values of Glutamate and Aspartate Residues in an Unfolded Protein by Multinuclear NMR Spectroscopy. J. Am. Chem. Soc. 124, 5714-5717 (2002). Epub 24 Apr 2002. (185.pdf) (185_SI.pdf) (DOI) (pubmed)

186.A. Mittermaier and Lewis E. Kay. Effect of Deuteration on Some Structural Parameters of Methyl Groups in Proteins as Evaluated by Residual Dipolar Couplings. J. Biomol. NMR 23, 35-45 (2002). (186.pdf) (DOI) (pubmed)

187.L.W. Donaldson, G. Gish, T. Pawson, Lewis E. Kay and J.D. Forman-Kay. Structure of a Regulatory Complex Involving the Abl SH3 Domain, the Crk SH2 Domain, and a Crk-Derived Phosphopeptide. Proc. Natl. Acad. Sci. USA 99, 14053-14058 (2002). Epub 16 Oct 2002. (187.pdf) (187_SI.tar) (DOI) (pubmed)

188.D.M. Korzhnev, N.R. Skrynnikov, O. Millet, D.A. Torchia and Lewis E. Kay. An NMR Experiment for the Accurate Measurement of Heteronuclear Spin-Lock Relaxation Rates. J. Am. Chem. Soc. 124, 10743-10753 (2002). Epub 17 Aug 2002. (188.pdf) (DOI) (pubmed)

189.V. Tugarinov, R. Muhandiram, A. Ayed and Lewis E. Kay. Four-Dimensional NMR Spectroscopy of a 723-Residue Protein: Chemical Shift Assignment and Secondary Structure of Malate Synthase G. J. Am. Chem. Soc. 124, 10025-10035 (2002). Epub 1 Aug 2002. (189.pdf) (189_SI.pdf) (DOI) (pubmed)

190.N.R. Skrynnikov, F.W. Dahlquist and Lewis E. Kay. Reconstructing NMR Spectra of “Invisible” Excited Protein States using HSQC and HMQC Experiments. J. Am. Chem. Soc. 124, 12352-12360 (2002). Epub 20 Sep 2002. (190.pdf) (190_SI.pdf) (DOI) (pubmed)

191.P.M. Hwang, W.-Y. Choy, E.I. Lo, L. Chen, J.D. Forman-Kay, C.R.H. Raetz, G.G. Privé, R.E. Bishop and Lewis E. Kay. Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR. Proc. Natl. Acad. Sci. USA 99, 13560-13565 (2002). Epub 30 Sep 2002. (191.pdf) (DOI) (pubmed)

192.T.K. Mal, M. Ikura and Lewis E. Kay. The ATCUN Domain as a Probe of Intermolecular Interactions: Application to Calmodulin-Peptide Complexes. J. Am. Chem. Soc. 124, 14002-14003 (2002). Epub 5 Nov 2002. (192.pdf) (192_SI.pdf) (DOI) (pubmed)

193.T.K. Mal, N.R. Skrynnikov, K.L. Yap, Lewis E. Kay and M. Ikura. Detecting Protein Kinase Recognition Modes of Calmodulin by Residual Dipolar Couplings in Solution NMR. Biochemistry (Accelerated) 41, 12899-12906 (2002). Epub 1 Oct 2002. (193.pdf) (DOI) (pubmed)

194.W.-Y. Choy, D. Shortle and Lewis E. Kay. Side Chain Dynamics in Unfolded Protein States: An NMR Based 2H Spin Relaxation Study of Δ131Δ. J. Am. Chem. Soc. 125, 1748-1758 (2003). Epub 25 Jan 2003. (194.pdf) (194_SI.pdf) (DOI) (pubmed)

195.M. Tollinger, K.A. Crowhurst, Lewis. E. Kay and J.D. Forman-Kay. Site-Specific Contributions to the pH Dependence of Protein Stability. Proc. Natl. Acad. Sci. USA 100, 4545-4550 (2003). Epub 1 Apr 2003. (195.pdf) (DOI) (pubmed)

196.V. Tugarinov and Lewis E. Kay. Quantitative NMR Studies of High Molecular Weight Proteins: Application to Domain Orientation and Ligand Binding in the 723 Residue Enzyme Malate Synthase G. J. Mol. Biol. 327, 1121-1133 (2003). Epub 28 Mar 2003. (196.pdf) (DOI) (pubmed)

197.W.-Y. Choy and Lewis E. Kay. Model Selection for the Interpretation of Protein Side Chain Methyl Dynamics. J. Biomol. NMR 25, 325-333 (2003). (197.pdf) (DOI) (pubmed)

198.D.M. Korzhnev, V.Y. Orekhov, F.W. Dahlquist and Lewis E. Kay. Off-resonance R Relaxation Outside of the Fast Exchange Limit: An Experimental Study of a Cavity Mutant of T4 Lysozyme. J. Biomol. NMR 25, 39-48 (2003). (198.pdf) (DOI) (pubmed)

199.V. Tugarinov and Lewis E. Kay. Side Chain Assignments of Ile δ1 Methyl Groups in High Molecular Weight Proteins: An Application to a 46 ns Tumbling Molecule. J. Am. Chem. Soc. 125, 5701-5706 (2003). Epub 18 Apr 2003. (199.pdf) (DOI) (pubmed)

200.O. Millet, A. Mittermaier, D. Baker and Lewis E. Kay. The Effects of Mutations on the Motions of Side-Chains in Protein L Studied by 2H NMR Dynamics and Scalar Couplings. J. Mol. Biol. 329, 551-563 (2003). Epub 21 May 2003. (200.pdf) (DOI) (pubmed)

201.J. E. Ollerenshaw, D.A. Lidar and Lewis E. Kay. A Magnetic Resonance Realization of Decoherence-Free Quantum Computation. Phys. Rev. Lett. 91, 217904 (2003). Epub 21 Nov 2003. (201.pdf) (DOI) (pubmed)

202.A. Mittermaier, A. R. Davidson and Lewis E. Kay. Correlation Between 2H NMR Side-Chain Order Parameters and Sequence Conservation in Globular Proteins. J. Am. Chem. Soc. 125, 9004-9005 (2003). Epub 8 Jul 2003. (202.pdf) (202_SI.pdf) (DOI) (pubmed)

203.V. Tugarinov, P.M. Hwang, J.E. Ollerenshaw and Lewis E. Kay. Cross-Correlated Relaxation Enhanced 1H-13C NMR Spectroscopy of Methyl Groups in Very High Molecular Weight Proteins and Protein Complexes. J. Am. Chem. Soc. 125, 10420-10428 (2003). Epub 5 Aug 2003. (203.pdf) (203_SI.pdf) (DOI) (pubmed)

204.J. E. Ollerenshaw, V. Tugarinov and Lewis E. Kay. Methyl TROSY: Explanation and Experimental Verification. Magn. Reson. Chem. 41, 843-852 (2003). Epub 9 Sep 2003. (204.pdf) (DOI)

205.E. Kupce, D.R. Muhandiram and Lewis E. Kay. A Combined HNCA/HNCO Experiment for 15N Labeled Proteins with 13C at Natural Abundance. J. Biomol. NMR 27, 175-179 (2003). (205.pdf) (DOI) (pubmed)

206.W.-Y. Choy and Lewis E. Kay. Probing Residual Interactions in Unfolded Protein States Using NMR Spin Relaxation Techniques: An Application to Δ131Δ. J. Am. Chem. Soc. 125, 11988-11992 (2003). Epub 6 Sep 2003. (206.pdf) (206_SI.pdf) (DOI) (pubmed)

207.V. Tugarinov and Lewis E. Kay. Ile, Leu, and Val Methyl Assignments of the 723-Residue Malate Synthase G Using a New Labeling Strategy and Novel NMR Methods. J. Am. Chem. Soc. 125, 13868-13878 (2003). Epub 16 Oct 2003. (207.pdf) (207_SI.pdf) (DOI) (pubmed)

208.V. Tugarinov and Lewis E. Kay. An Isotope Labeling Strategy for Methyl TROSY Spectroscopy. J. Biomol. NMR 28, 165-172 (2004). (208.pdf) (DOI) (pubmed)

209.O. Millet, R.P. Hudson and Lewis E. Kay. The Energetic Cost of Domain Reorientation in Maltose-Binding Protein as Studied by NMR and Fluorescence Spectroscopy. Proc. Natl. Acad. Sci. USA 100, 12700-12705 (2003). Epub 6 Oct 2003. (209.pdf) (DOI) (pubmed)

210.A. Mittermaier and Lewis E. Kay. The Response of Internal Dynamics to Hydrophobic Core Mutations in the SH3 Domain from the Fyn Tyrosine Kinase. Protein Sci. 13, 1088-1099 (2004). (210.pdf) (DOI) (pubmed)

211.V.Y. Orekhov, D.M. Korzhnev and Lewis E. Kay. Double- and Zero-Quantum Relaxation Dispersion Experiments Sampling Millisecond Time-Scale Dynamics in Proteins. J. Am. Chem. Soc. 126, 1886-1891 (2004). Epub 22 Jan 2004. (211.pdf) (DOI) (pubmed)

212.V. Tugarinov, P.M. Hwang and Lewis E. Kay, Nuclear Magnetic Resonance Spectroscopy of High Molecular Weight Proteins. Annu. Rev. Biochem. 73, 107-146 (2004). Epub 2 Apr 2004. (212.pdf) (DOI) (pubmed)

213.V.E. Ahn, E.I. Lo, C.K. Engel, L. Chen, P.M. Hwang, Lewis E. Kay, R.E. Bishop and G.G. Privé. A Hydrocarbon Ruler Measures Palmitate in the Enzymatic Acylation of Endotoxin. EMBO J. 23, 2931-2941 (2004). Epub 22 Jul 2004. (213.pdf) (DOI) (pubmed)

214.A.A. Di Nardo, D.M. Korzhnev, P.J. Stogios, A. Zarrine-Afsar, Lewis E. Kay, and A.R. Davidson. Dramatic Acceleration of Protein Folding by Stabilization of a Nonnative Backbone Conformation. Proc. Natl. Acad. Sci. USA 101, 7954-7959 (2004). Epub 17 May 2004. (214.pdf) (214_SI.tar) (DOI) (pubmed)

215.D.M. Korzhnev, X. Salvatella, M. Vendruscolo, A.A. Di Nardo, A.R. Davidson, C.M. Dobson and Lewis E. Kay. Low-Populated Folding Intermediates of Fyn SH3 Characterized by Relaxation Dispersion NMR. Nature 430, 586-590 (2004). (215.pdf) (215_SI.pdf) (DOI) (pubmed)

216.D.M. Korzhnev, K. Kloiber and Lewis E. Kay. Multiple-Quantum Relaxation Dispersion NMR Spectroscopy Probing Millisecond Time-Scale Dynamics in Proteins: Theory and Application. J. Am. Chem. Soc. 126, 7320-7329 (2004). Epub 20 May 2004. (216.pdf) (DOI) (pubmed)

217.D.M. Korzhnev, K. Kloiber, V. Kanelis, V. Tugarinov and Lewis E. Kay. Probing Slow Dynamics in High Molecular Weight Proteins by Methyl-TROSY NMR Spectroscopy: Application to a 723-Residue Protein. J. Am. Chem. Soc. 126, 3964-3973 (2004). Epub 9 Mar 2004. (217.pdf) (217_SI.pdf) (DOI) (pubmed)

218.V. Tugarinov and Lewis E. Kay. 1H,13C-1H,1H Dipolar Cross-Correlated Spin Relaxation in Methyl Groups. J. Biomol. NMR 29, 369-376 (2004). (218.pdf) (DOI) (pubmed)

219.V. Tugarinov, R. Sprangers and Lewis E. Kay. Line Narrowing in Methyl-TROSY Using Zero-Quantum 1H-13C NMR Spectroscopy. J. Am. Chem. Soc. 126, 4921-4925 (2004). Epub 26 Mar 2004. (219.pdf) (219_SI.pdf) (DOI) (pubmed)

220.V. Tugarinov and Lewis E. Kay. Stereospecific NMR Assignments of Prochiral Methyls, Rotameric States and Dynamics of Valine Residues in Malate Synthase G. J. Am. Chem. Soc. 126, 9827-9836 (2004). Epub 16 Jul 2004. (220.pdf) (220_SI.pdf) (DOI) (pubmed)

221.P.M. Hwang, R.E. Bishop and Lewis E. Kay. The Integral Membrane Enzyme PagP Alternates Between Two Dynamically Distinct States. Proc. Natl. Acad. Sci. USA 101, 9618-9623 (2004). Epub 21 Jun 2005. (221.pdf) (221_SI.pdf) (DOI) (pubmed)

222.P.M. Hwang and Lewis E. Kay. Solution Structure and Dynamics of Integral Membrane Proteins by NMR: A Case Study Involving the Enzyme PagP. Methods Enzymol. 394, 335-350 (2005). Epub 4 Apr 2005. (222.pdf) (DOI) (pubmed)

223.V. Tugarinov, W.-Y. Choy, E. Kupče and Lewis E. Kay. Addressing the Overlap Problem in the Quantitative Analysis of Two Dimensional NMR Spectra: Application to 15N Relaxation Experiments. J. Biomol. NMR 30, 347-352 (2004). (223.pdf) (DOI) (pubmed)

224.J.E. Ollerenshaw, H. Kaya, H.S. Chan and Lewis E. Kay. Sparsely Populated Folding Intermediates of the Fyn SH3 Domain: Matching Native-Centric Essential Dynamics and Experiment. Proc. Natl. Acad. Sci. USA 101, 14748-14753 (2004). Epub 5 Oct 2004. (224.pdf) (224_SI.pdf) (DOI) (pubmed)

225.P.J. Finerty Jr., A.K. Mittermaier, R. Muhandiram, Lewis E. Kay and J.D. Forman-Kay. NMR Dynamics-Derived Insights into the Binding Properties of a Peptide Interacting with an SH2 Domain. Biochemistry 44, 694-703 (2005). Epub 16 Dec 2004. (225.pdf) (225_SI.tar) (DOI) (pubmed)

226.V. Tugarinov, C. Scheurer, R. Brüschweiler and Lewis E. Kay. Estimates of Methyl 13C and 1H CSA Values (Δσ) in Proteins from Cross-Correlated Spin Relaxation. J. Biomol. NMR 30, 397-406 (2004). (226.pdf) (DOI) (pubmed)

227.J. Xu, O. Millet, Lewis E. Kay and N.R. Skrynnikov. A New Spin Probe of Protein Dynamics: Nitrogen Relaxation in 15N-2H Amide Groups. J. Am. Chem. Soc. 127, 3220-3229 (2005). Epub 12 Feb 2005. (227.pdf) (227_SI.pdf) (DOI) (pubmed)

228.D.M. Korzhnev, V.Y. Orekhov and Lewis E. Kay. Off-resonance R NMR Studies of Exchange Dynamics in Proteins with Low Spin-Lock Fields: An Application to a Fyn SH3 Domain. J. Am. Chem. Soc. 127, 713-721 (2005). Epub 22 Dec 2004. (228.pdf) (DOI) (pubmed)

229.V. Tugarinov, Lewis E. Kay, I. Ibraghimov and V.Y. Orekhov. High-Resolution Four-Dimensional 1H-13C NOE Spectroscopy Using Methyl-TROSY, Sparse Data Acquisition, and Multidimensional Decomposition. J. Am. Chem. Soc. 127, 2765-2775 (2005). Epub 1 Feb 2005. (229.pdf) (DOI) (pubmed)

230.V. Tugarinov, W.-Y. Choy, V.Y. Orekhov and Lewis E. Kay. Solution NMR-Derived Global Fold of a Monomeric 82 kDa Protein. Proc. Natl. Acad. Sci. 102, 622-627 (2005). Epub 6 Jan 2005. (230.pdf) (230_SI.tar) (DOI) (pubmed)

231.Lewis E. Kay. NMR Studies of Protein Structure and Dynamics. J. Magn. Reson. 173, 193-207 (2005). Epub 20 Dec 2004. (231.pdf) (DOI) (pubmed)

232.P. Vallurupalli and Lewis E. Kay. A Suite of 2H NMR Spin Relaxation Experiments for the Measurement of RNA Dynamics. J. Am. Chem. Soc. 127, 6893-6901 (2005). Epub 19 Apr 2005. (232.pdf) (232_SI.pdf) (DOI) (pubmed)

233.W.-Y. Choy, Z. Zhou, Y. Bai and Lewis E. Kay. An 15N NMR Spin Relaxation Dispersion Study of the Folding of a Pair of Engineered Mutants of Apocytochrome b562. J. Am. Chem. Soc. 127, 5066-5072 (2005). Epub 19 Mar 2005. (233.pdf) (DOI) (pubmed)

234.D.M. Korzhnev, A.K. Mittermaier and Lewis E. Kay. Cross-Correlated Spin Relaxation Effects in 1H Methyl CPMG-Based Relaxation Dispersion Experiments: Complications and a Simple Solution. J. Biomol. NMR 31, 337-342 (2005). (234.pdf) (DOI) (pubmed)

235.M.A. Pufall, G.M. Lee, M.L. Nelson, H.-S. Kang, A. Velyvis, Lewis E. Kay, L.P. McIntosh and B.J. Graves. Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region. Science 309, 142-145 (2005). (235.pdf) (235_SI.pdf) (DOI) (pubmed)

236.V. Tugarinov and Lewis E. Kay. Methyl Groups as Probes of Structure and Dynamics in NMR Studies of High-Molecular-Weight Proteins. Chembiochem 6, 1567-1577 (2005). (236.pdf) (DOI) (pubmed)

237.M. Tollinger, Lewis E. Kay and J.D. Forman-Kay. Measuring pKa Values in Protein Folding Transition State Ensembles by NMR Spectroscopy. J. Am. Chem. Soc. 127, 8904-8905 (2005). Epub 1 Jun 2005. (237.pdf) (237_SI.pdf) (DOI) (pubmed)

238.V. Tugarinov, J.E. Ollerenshaw and Lewis E. Kay. Probing Side-Chain Dynamics in High Molecular Weight Proteins by Deuterium NMR Spin Relaxation: An Application to an 82-kDa Enzyme. J. Am. Chem. Soc. 127, 8214-8225 (2005). Epub 13 May 2005. (238.pdf) (DOI) (pubmed)

239.J.E. Ollerenshaw, V. Tugarinov and Lewis E. Kay. Comparison of 13CH3, 13CH2D, and 13CHD2 Methyl Labeling Strategies in Proteins. J. Biomol. NMR 33, 25-41 (2005). (239.pdf) (DOI) (pubmed)

240.E.Z. Eisenmesser, O. Millet, W. Labeikovsky, D.M. Korzhnev, M. Wolf-Watz, D.A. Bosco, J.J. Skalicky, Lewis E. Kay and D. Kern. Intrinsic Dynamics of an Enzyme Underlies Catalysis. Nature 438, 117-121 (2005). (240.pdf) (240_SI.tar) (DOI) (pubmed)

241.R. Sprangers, A, Gribun, P.M. Hwang, W.A. Houry and Lewis E. Kay. Quantitative NMR Spectroscopy of Supramolecular Complexes: Dynamic Side Pores in ClpP are Important for Product Release. Proc. Natl. Acad. Sci. USA 102, 16678-16683 (2005). Epub 1 Nov 2005. (241.pdf) (DOI) (pubmed)

242.D.M. Korzhnev, P. Neudecker, A. Mittermaier, V.Y. Orhekov and Lewis E. Kay. Multiple-Site Exchange in Proteins Studied with a Suite of Six NMR Relaxation Dispersion Experiments: An Application to the Folding of a Fyn SH3 Domain Mutant. J. Am. Chem. Soc. 127, 15602-15611 (2005). Epub 12 Oct 2005. (242.pdf) (242_SI.pdf) (DOI) (pubmed)

243.A. Mittermaier, D.M. Korzhnev and Lewis E. Kay. Side-Chain Interactions in the Folding Pathway of a Fyn SH3 Domain Mutant Studied by Relaxation Dispersion NMR Spectroscopy. Biochemistry (Accelerated) 44, 15430-15436 (2005). (243.pdf) (243_SI.pdf) (DOI) (pubmed)

244.V. Tugarinov and Lewis E. Kay. Quantitative 13C and 2H NMR Studies of the 723-Residue Enzyme Malate Synthase G Reveal a Highly Dynamic Binding Interface. Biochemistry (Accelerated) 44, 15970-15977 (2005). (244.pdf) (244_SI.pdf) (DOI) (pubmed)

245.A. Zarrine-Afsar, A. Mittermaier, Lewis E. Kay and A.R. Davidson. Protein Stabilization by Specific Binding of Guanidinium to a Functional Arginine-Binding Surface on an SH3 Domain. Protein Sci. 15, 162-170 (2006). (245.pdf) (DOI) (pubmed)

246.P. Neudecker, D.M. Korzhnev and Lewis E. Kay. Assessment of the Effects of Increased Relaxation Dispersion Data on the Extraction of 3-Site Exchange Parameters Characterizing the Unfolding of an SH3 Domain. J. Biomol NMR 34, 129-135 (2006). (246.pdf) (DOI) (pubmed)

247.U. Brath, M. Akke, D. Yang, Lewis E. Kay and F.A.A. Mulder. Functional Dynamics of Human FKBP12 Revealed by Methyl 13C Rotating Frame Relaxation Dispersion NMR Spectroscopy. J. Am. Chem. Soc. 128, 5718-5727 (2006). Epub 11 Apr 2006. (247.pdf) (247_SI.pdf) (DOI) (pubmed)

248.V. Tugarinov, J. E. Ollerenshaw and Lewis E. Kay. Dipolar Dynamic Frequency Shifts in Multiple Quantum Spectra of Methyl Groups in Proteins: Correlation with Side-Chain Motion. Magn. Reson. Chem. 44, S122-S129 (2006). Epub 6 Jul 2006. (248.pdf) (DOI) (pubmed)

249.V. Tugarinov and Lewis E. Kay. Relaxation Rates of Degenerate 1H Transitions in Methyl Groups of Proteins as Reporters of Side-Chain Dynamics. J. Am. Chem. Soc. 128, 7299-7308 (2006). Epub 12 May 2006. (249.pdf) (249_SI.pdf) (DOI) (pubmed)

250.D.M. Korzhnev, I. Bezsonova, F. Evanics, N. Taulier, Z. Zhou, Y. Bai, T.V. Chalikian, R.S. Prosser and Lewis E. Kay. Probing the Transition State Ensemble of a Protein Folding Reaction by Pressure Dependent NMR Relaxation Dispersions. J. Am. Chem. Soc. 128, 5262-5269 (2006). Epub 23 Mar 2006. (250.pdf) (250_SI.pdf) (DOI) (pubmed)

251.I. Bezsonova, D.M. Korzhnev, R.S. Prosser, J.D. Forman-Kay and Lewis E. Kay. Hydration and Packing Along the Folding Pathway of SH3 Domains by Pressure-Dependent NMR. Biochemistry (Accelerated) 45, 4711-4719 (2006). Epub 22 Mar 2006. (251.pdf) (251_SI.pdf) (DOI) (pubmed)

252.M. Tollinger, C. Neale, Lewis E. Kay and J.D. Forman-Kay. Characterization of the Hydrodynamic Properties of the Folding Transition State of an SH3 Domain by Magnetization Transfer NMR Spectroscopy. Biochemistry 45, 6434-6445 (2006). Epub 27 Apr 2006. (252.pdf) (DOI) (pubmed)

253.A. Mittermaier and Lewis E. Kay. New Tools Provide New Insights in NMR Studies of Protein Dynamics. Science 312, 224-228 (2006). (253.pdf) (DOI) (pubmed)

254.F. Evanics, P.M. Hwang, Y. Cheng, Lewis E. Kay, and R.S. Prosser. Topology of an Outer-Membrane Enzyme: Measuring Oxygen and Water Contacts in Solution NMR Studies of PagP. J. Am. Chem. Soc. 128, 8256-8264 (2006). Epub 7 Jun 2006. (254.pdf) (DOI) (pubmed)

255.P. Vallurupalli and Lewis E. Kay. Complementarity of Ensemble and Single-Molecule Measures of Protein Motion: A Relaxation Dispersion NMR Study of an Enzyme System. Proc. Natl. Acad. Sci. USA 103, 11910-11915 (2006). Epub 31 Jul 2006. (255.pdf) (255_SI.tar) (DOI) (pubmed)

256.V. Tugarinov and Lewis E. Kay. A 2H NMR Experiment for the Measurement of the Time Scale of Methyl Side-Chain Dynamics in Large Proteins. J. Am. Chem. Soc. 128, 12484-12489 (2006). Epub 2 Sep 2006. (256.pdf) (256_SI.pdf) (DOI) (pubmed)

257.V. Tugarinov, V. Kanelis and Lewis E. Kay. Isotope Labeling Strategies for the Study of High-Molecular-Weight Proteins by Solution NMR Spectroscopy. Nat. Protoc. 1, 749-754 (2006). Epub 13 Jul 2006. (257.pdf) (DOI) (pubmed)

258.P. Vallurupalli, L. Scott. M. Hennig, J.R. Williamson and Lewis E. Kay. New RNA Labeling Methods Offer Dramatic Sensitivity Enhancements in 2H Relaxation Spectra. J. Am. Chem. Soc. 128, 9346-9347 (2006). Epub 30 Jun 2006. (258.pdf) (258_SI.pdf) (DOI) (pubmed)

259.D.M. Korzhnev, P. Neudecker, A. Zarrine-Afsar, A.R. Davidson and Lewis E. Kay, Abp1p and Fyn SH3 Domains Fold Through Similar Low-Populated Intermediate States. Biochemistry (Accelerated) 45, 10175-10183 (2006). Epub 3 Aug 2006. (258.pdf) (259_SI.pdf) (DOI) (pubmed)

260.P. Neudecker, A. Zarrine-Afsar, W.-Y. Choy, D.R. Muhandiram, A.R. Davidson and Lewis E. Kay. Identification of a Collapsed Intermediate with Non-Native Long-Range Interactions on the Folding Pathway of a Pair of Fyn SH3 Domain Mutants by NMR Relaxation Dispersion Spectroscopy. J. Mol. Biol. 363, 958-976 (2006). Epub 22 Aug 2006. (260.pdf) (DOI) (pubmed)

261.R. Sprangers and Lewis E. Kay. Quantitative Dynamics and Binding Studies of the 20S Proteasome by NMR. Nature 445, 618-622 (2007). Epub 21 Jan 2007. (261.pdf) (261_SI.pdf) (DOI) (pubmed)

262.V. Tugarinov, R. Sprangers and Lewis E. Kay, Probing Side-Chain Dynamics in the Proteasome by Relaxation Violated Coherence Transfer NMR Spectroscopy. J. Am. Chem. Soc. 129, 1743-1750 (2007). Epub 24 Jan 2007. (262.pdf) (262_SI.pdf) (DOI) (pubmed)

263.D.F. Hansen and Lewis E. Kay. Improved Magnetization Alignment Schemes for Spin-Lock Relaxation Experiments. J. Biomol. NMR 37, 245-255 (2007). Epub 20 Feb 2007. (263.pdf) (263_SI.pdf) (DOI) (pubmed)

264.Lewis E. Kay. The Molecular Dance of a Protein Molecule Allows a Chemist’s Secret Wish to Come True. Nature 444, 657 (2006). (264.pdf) (DOI)

265.A. Zhuravleva, D.M. Korzhnev, S.B. Nolde, Lewis E. Kay, A.S. Arseniev, M. Billeter and V.Y. Orekhov. Propagation of Dynamic Changes in Barnase upon Binding Barstar: An NMR and Computational Study. J. Mol. Biol. 367, 1079-1092 (2007). Epub 24 Jan 2007. (265.pdf) (DOI) (pubmed)

266.P. Vallurupalli, L. Scott, J.R. Williamson and Lewis E. Kay. Strong Coupling Effects During X-Pulse CPMG Experiments Recorded on Heteronuclear ABX Spin Systems: Artifacts and a Simple Solution. J Biomol. NMR 38, 41-46 (2007). Epub 3 Mar 2007. (266.pdf) (DOI) (pubmed)

267.P. Lündstrom, P. Vallurupalli, T. Religa, F.W. Dahlquist and Lewis E. Kay. A Single-Quantum Methyl 13C-Relaxation Dispersion Experiment with Improved Sensitivity. J Biomol. NMR 38, 79-88 (2007). Epub 27 Apr 2007. (267.pdf) (DOI) (pubmed)

268.P. Lündstrom, K. Teilum, T. Carstensen, I. Bezsonova, S. Wiesner, D.F. Hansen, T.L. Reglia, M. Akke and Lewis E. Kay. Fractional 13C Enrichment of Isolated Carbons Using [1-13C]- or [2-13C]-Glucose Facilitates the Accurate Measurement of Dynamics at Backbone Cα and Side-Chain Methyl Positions in Proteins. J Biomol. NMR 38, 199-212 (2007). Epub 7 Jun 2007. (268.pdf) (DOI) (pubmed)

269.R. Sprangers, A. Velyvis and Lewis E. Kay. Solution NMR Studies of Supramolecular Complexes: Providing New Insights into Function. Nat. Methods 4, 697-703 (2007). Epub 30 Aug 2007. (269.pdf) (DOI) (pubmed)

270.A. Velyvis, Y.R. Yang, H.K. Schachman and Lewis E. Kay. A Solution NMR Study Showing that Active Site Ligands and Nucleotides Directly Perturb the Allosteric Equilibrium in Aspartate Transcarbamoylase. Proc. Natl. Acad. Sci. USA 104, 8815-8820 (2007). Epub 14 May 2007. (270.pdf) (270_SI.tar) (DOI) (pubmed)

271.V. Tugarinov and Lewis E. Kay. Separating Degenerate 1H Transitions in Methyl Group Probes for Single-Quantum 1H-CPMG Relaxation Dispersion NMR Spectroscopy. J. Am. Chem. Soc. 129, 9514-9521 (2007). Epub 12 Jul 2007. (271.pdf) (DOI) (pubmed)

272.D.F. Hansen, D. Yang, H. Feng, Z. Zhou, S. Wiesner, Y. Bai and Lewis E. Kay. An Exchange-Free Measure of 15N Transverse Relaxation: An NMR Spectroscopy Application to the Study of a Folding Intermediate with Pervasive Chemical Exchange Contributions. J. Am. Chem. Soc. 129, 11468-11479 (2007). Epub 28 Aug 2007. (272.pdf) (272_SI.pdf) (DOI) (pubmed)

273.D.M. Korzhnev, T.L. Religa, P. Lündstrom, A.R. Fersht and Lewis E. Kay. The Folding Pathway of an FF Domain: Characterization of an On-Pathway Intermediate State Under Folding Conditions by 15N, 13Cα and 13C-Methyl Relaxation Dispersion and 1H/2H-exchange NMR Spectroscopy. J. Mol. Biol. 372, 497-512 (2007). Epub 9 Jun 2007. (273.pdf) (273_SI.pdf) (DOI) (pubmed)

274.J.M. Murphy, D.M. Korzhnev, D.F. Ceccarelli, D.J. Briant, A. Zarrine-Afsar, F. Sicheri, Lewis E. Kay and T. Pawson. Conformational Instability of the MARK3 UBA Domain Compromises Ubiquitin Recognition and Promotes Interaction with the Adjacent Kinase Domain. Proc. Natl. Acad. Sci. USA 104, 14336-14341 (2007). Epub 28 Aug 2007. (274.pdf) (274_SI.tar) (DOI) (pubmed)

275.P. Neudecker, A. Zarrine-Afsar, A.R. Davidson and Lewis E. Kay. Φ-Value Analysis of a Three-State Protein Folding Pathway by Relaxation Dispersion NMR Spectroscopy. Proc. Natl. Acad. Sci. USA 104, 15717-15722 (2007). Epub 26 Sep 2007. (275.pdf) (275_SI.tar) (DOI) (pubmed)

276.P. Vallurupalli, D.F. Hansen, E. Stollar, E. Meirovitch and Lewis E. Kay. Measurement of Bond Vector Orientations in Invisible Excited States of Proteins. Proc. Natl. Acad. Sci. USA 104, 18473-18477 (2007). Epub 15 Nov 2007. (276.pdf) (276_SI.tar) (DOI) (pubmed)

277.R. Sprangers and Lewis E. Kay. Probing Supramolecular Structure from Measurement of Methyl 1H-13C Residual Dipolar Couplings. J. Am. Chem. Soc. 129, 12668-12669 (2007). Epub 2 Oct 2007. (277.pdf) (277_SI.pdf) (DOI) (pubmed)

278.D.F. Hansen, P. Vallurupalli and Lewis E. Kay. An Improved 15N Relaxation Dispersion Experiment for the Measurement of Millisecond Time-Scale Dynamics in Proteins. J. Phys. Chem. B 112, 5898-5904 (2008). Epub 15 Nov 2007. (278.pdf) (DOI) (pubmed)

279.A. Grishaev, V. Tugarinov, Lewis E. Kay, J. Trewhella and Ad Bax. Refined Solution Structure of the 82-kDa Enzyme Malate Synthase G from Joint NMR and Synchrotron SAXS Restraints. J. Biomol. NMR 40, 95-106 (2008). Epub 16 Nov 2007. (279.pdf) (279_SI.pdf) (DOI) (pubmed)

280.Z. Zhou, H. Feng, D.F. Hansen, E. Luk, H. Kato, D.I. Freedberg, Lewis E. Kay, C. Wu and Y. Bai. NMR Structure of Chaperone Chz1 Complexed with Histones H2A.Z-H2B. Nat. Struct. Mol. Biol. 15, 868-869 (2008). Epub 20 Jul 2008. (280.pdf) (280_SI.pdf) (DOI) (pubmed)

281.D.M. Korzhnev and Lewis E. Kay. Probing Invisible, Low-Populated States of Protein Molecules by Relaxation Dispersion NMR Spectroscopy: An Application to Protein Folding. Acc. Chem. Res. 41, 442-451 (2008). Epub 15 Feb 2008. (281.pdf) (DOI) (pubmed)

282.T. Mittag, S. Orlicky, W.-Y. Choy, X. Tang, H. Lin, F. Sicheri, Lewis E. Kay, M. Tyers and J.D. Forman-Kay. Dynamic Equilibrium Engagement of a Polyvalent Ligand with a Single-Site Receptor. Proc. Natl. Acad. Sci. USA 105, 17772-17777 (2008). Epub 13 Nov 2008. (282.pdf) (282_SI.pdf) (DOI) (pubmed)

283.D.F. Hansen, P. Vallurupalli, P. Lundström, P. Neudecker and Lewis. E. Kay. Probing Chemical Shifts of Invisible States of Proteins with Relaxation Dispersion NMR Spectroscopy: How Well Can We Do? J. Am. Chem. Soc. 130, 2667-2675 (2008). Epub 1 Feb 2008. (283.pdf) (283_SI.pdf) (DOI) (pubmed)

284.P. Vallurupalli, D.F. Hansen and Lewis. E. Kay. Probing Structure in Invisible Protein States with Anisotropic NMR Chemical Shifts. J. Am. Chem. Soc. 130, 2734-2735 (2008). Epub 8 Feb 2008. (284.pdf) (284_SI.pdf) (DOI) (pubmed)

285.D.F. Hansen, P. Vallurupalli and Lewis E. Kay. Quantifying Two-Bond 1HN-13CO and One-Bond 1Hα-13Cα Dipolar Couplings of Invisible Protein States by Spin-State Selective Relaxation Dispersion NMR Spectroscopy. J. Am. Chem. Soc. 130, 8397-8405 (2008). Epub 3 Jun 2008. (285.pdf) (DOI) (pubmed)

286.M.A.S. Hass, D.F. Hansen, H.E.M. Christensen, J.J. Led and Lewis E. Kay. Characterization of Conformational Exchange of a Histidine Side Chain: Protonation, Rotamerization, and Tautomerization of His 61 in Plastocyanin from Anabaena variabilis. J. Am. Chem. Soc. 130, 8460-8470 (2008). Epub 7 Jun 2008. (286.pdf) (286_SI.pdf) (DOI) (pubmed)

287.R. Sprangers, X. Li, X. Mao, J.L. Rubinstein, A.D. Schimmer and Lewis E. Kay. TROSY-Based NMR Evidence for a Novel Class of 20S Proteasome Inhibitor. Biochemistry (Accelerated) 47, 6727-6734 (2008). Epub 10 Jun 2008. (287.pdf) (287_SI.pdf) (DOI) (pubmed)

288.X. Mao, X. Li, R. Sprangers, X. Wang, A. Vengopal, T. Wood, Y, Zhang, D.A. Kuntz, E. Coe, S. Trudel, D. Rose, R.A. Batey, Lewis E. Kay and A.D. Schimmer. Clioquinol Inhibits the Proteasome and Displays Preclinical Activity in Leukemia and Myeloma. Leukemia 23, 585-590 (2009). Epub 28 Aug 2008. (288.pdf) (288_SI.tar) (DOI) (pubmed)

289.D.F. Hansen, P. Vallurupalli and Lewis E. Kay. Using Relaxation Dispersion NMR Spectroscopy to Determine Structures of Excited, Invisible Protein States. J. Biomol. NMR 41, 113-120 (2008). Epub 24 Jun 2008. (289.pdf) (DOI) (pubmed)

290.P. Vallurupalli, D.F. Hansen and Lewis E. Kay. Structures of Invisible, Excited Protein States by Relaxation Dispersion NMR Spectroscopy. Proc. Natl. Acad. Sci. USA 105, 11766-11771 (2008). Epub 13 Aug 2008. (290.pdf) (290_SI.pdf) (DOI) (pubmed)

291.P. Lundström, D.F. Hansen and Lewis E. Kay. Measurement of Carbonyl Chemical Shifts of Excited Protein States by Relaxation Dispersion NMR spectroscopy: Comparison Between Uniformly and Selectively 13C Labeled Samples. J. Biomol NMR 42, 35-47 (2008). Epub 2 Sep 2008. (291.pdf) (DOI) (pubmed)

292.P. Fillippakopoulos, M. Kofler, O. Hantschel, G.D. Gish, F. Grebien, E. Salah, P. Neudecker, Lewis E. Kay, B.E. Turk, G. Superti-Furga, T. Pawson and S. Knapp. Structural Coupling of SH2-kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation. Cell 134, 793-803 (2008). Epub 4 Sep 2008. (292.pdf) (292_SI.pdf) (DOI) (pubmed)

293.P. Lundström, D.F. Hansen, P. Vallurupalli and Lewis E. Kay. Accurate Measurement of Alpha Proton Chemical Shifts of Excited Protein States by Relaxation Dispersion NMR Spectroscopy. J. Am. Chem. Soc. 131, 1915-1926 (2009). Epub 16 Jan 2009. (293.pdf) (293_SI.pdf) (DOI) (pubmed)

294.D.M. Korzhnev, I. Bezsonova, S. Lee, T.V. Chalikian, and Lewis E. Kay. Alternate Binding Modes for a Ubiquitin-SH3 Domain Interaction Studied by NMR Spectroscopy. J. Mol. Biol. 386, 391-405 (2009). Epub 6 Dec 2008. (294.pdf) (DOI) (pubmed)

295.D.F. Hansen, Z. Zhou, H. Feng, L.M.M. Jenkins, Y. Bai and Lewis E. Kay. Binding Kinetics of Histone Chaperone Chz1 and Variant Histone H2A.Z-H2B by Relaxation Dispersion NMR Spectroscopy. J. Mol. Biol. 387, 1-9 (2009). Epub 20 Jan 2009. (295.pdf) (DOI) (pubmed)

296.P. Neudecker, P. Lundström and Lewis E. Kay. Relaxation Dispersion NMR Spectroscopy as a Tool for Detailed Studies of Protein Folding. Biophys. J. 96, 2045-2054 (2009). Epub 13 Mar 2009. (296.pdf) (DOI) (pubmed)

297.A. Velyvis, H.K. Schachman and Lewis E. Kay. Application of Methyl-TROSY NMR to Test Allosteric Models Describing Effects of Nucleotide Binding to Aspartate Transcarbamoylase. J. Mol. Biol. 387, 540-547 (2009). Epub 4 Feb 2009. (297.pdf) (DOI) (pubmed)

298.P. Vallurupalli, D.F. Hansen, P. Lundström and Lewis E. Kay. CPMG Relaxation Dispersion NMR Experiments Measuring Glycine 1Hα and 13Cα Chemical Shifts in the ‘Invisible’ Excited States of Proteins. J. Biomol. NMR 45, 45-55 (2009). Epub 25 Mar 2009. (298.pdf) (298_SI.pdf) (DOI) (pubmed)

299.P. Lundström, H. Lin and Lewis E. Kay. Measuring 13Cβ Chemical Shifts of Invisible Excited States in Protein by Relaxation Dispersion NMR Spectroscopy. J. Biomol. NMR 44, 139-155 (2009). Epub 16 May 2009. (299.pdf) (DOI) (pubmed)

300.D.F. Hansen, P. Vallurupalli and Lewis E. Kay. Measurement of Methyl Group Motional Parameters of Invisible, Excited Protein States by NMR Spectroscopy. J. Am. Chem. Soc. 131, 12745-12754 (2009). Epub 17 Aug 2009. (300.pdf) (300_SI.pdf) (DOI) (pubmed)

301.T. Mittag, Lewis E. Kay and J.D. Forman-Kay. Protein Dynamics and Conformational Disorder in Molecular Recognition. J. Mol. Recognit. 23, 105-116 (2010). Epub 7 Jul 2009. (301.pdf) (DOI) (pubmed)

302.H. van Ingen, D.M. Korzhnev and Lewis E. Kay. An Analysis of the Effects of 1HN-1HN Dipolar Couplings on the Measurement of Amide Bond Vector Orientations in Invisible Protein States by Relaxation Dispersion NMR. J. Phys. Chem. B 113, 9968-9977 (2009). Epub 1 Jul 2009. (302.pdf) (DOI) (pubmed)

303.R. Auer, P. Neudecker, D.R. Muhandiram, P. Lundström, D.F. Hansen, R. Konrat and Lewis E. Kay. Measuring the Signs of 1Hα Chemical Shift Differences Between Ground and Excited Protein States by Off-Resonance Spin-Lock R NMR Spectroscopy. J. Am. Chem. Soc. 131, 10832-10833 (2009). Epub 16 Jul 2009. (303.pdf) (303_SI.pdf) (DOI) (pubmed)

304.A.J. Baldwin, D.F. Hansen, P. Vallurupalli and Lewis E. Kay. Measurement of Methyl Axis Orientations in Invisible, Excited States of Proteins by Relaxation Dispersion NMR Spectroscopy. J. Am. Chem. Soc. 131, 11939-11948 (2009). Epub 24 Jul 2009. (304.pdf) (304_SI.pdf) (DOI) (pubmed)

305.P. Lundström, P. Vallurupalli, D.F. Hansen and Lewis E. Kay. Isotope Labeling Methods for Studies of Excited Protein States by Relaxation Dispersion NMR Spectroscopy. Nat. Protoc. 4, 1641-1648 (2009). Epub 22 Oct 2009. (305.pdf) (DOI) (pubmed)

306.J.M. Murphy, D.F. Hansen, S. Wiesner, D.R. Muhandiram, M. Borg, M.J. Smith, F. Sicheri, Lewis E. Kay, J.D. Forman-Kay and T. Pawson. Structural Studies of FF Domains of the Transcription Factor CA150 Provide Insights into the Organization of FF Domain Tandem Arrays. J. Mol. Biol. 339, 409-424 (2009). Epub 26 Aug 2009. (306.pdf) (306_SI.tar) (DOI) (pubmed)

307.A.K. Mittermaier and Lewis E. Kay. Observing Biological Dynamics at Atomic Resolution Using NMR. Trends Biochem. Sci. 34, 601-611 (2009). Epub 19 Oct 2009. (307.pdf) (DOI) (pubmed)

308.A.J. Baldwin and Lewis E. Kay. NMR Spectroscopy Brings Invisible Protein States into Focus. Nat. Chem. Biol. 5, 808-814 (2009). Epub 19 Oct 2009. (308.pdf) (DOI) (pubmed)

309.A.M. Ruschak and Lewis E. Kay. Methyl Groups as Probes of Supra-Molecular Structure, Dynamics and Function. J. Biomol. NMR 46, 75-87 (2010). Epub 27 Sept 2009. (309.pdf) (DOI) (pubmed)

310.D.F. Hansen, H. Feng, Z. Zhou, Y. Bai and Lewis E. Kay. Selective Characterization of Microsecond Motions in Proteins by NMR Relaxation. J. Am. Chem. Soc. 131, 16257-16265 (2009). Epub 20 Oct 2009. (310.pdf) (310_SI.pdf) (DOI) (pubmed)

311.A. Velyvis, H.K. Schachman and Lewis E. Kay. Assignment of Ile, Leu, and Val Methyl Correlations in Supra-Molecular Systems: An Application to Aspartate Transcarbamoylase. J. Am. Chem. Soc. 131, 16534-16543 (2009). Epub 27 Oct 2009. (311.pdf) (311_SI.pdf) (DOI) (pubmed)

312.F. Stengel, A.J. Baldwin, A.J. Painter, N. Jaya, E. Basha, Lewis E. Kay, E. Vierling, C.V. Robinson and J.L. Benesch. Quaternary Dynamics and Plasticity Underlie Small Heat Shock Chaperone Function. Proc. Natl. Acad. Sci. USA 107, 2007-2012 (2010). Epub 19 Jan 2010. (312.pdf) (312_SI.pdf) (DOI) (pubmed)

313.R. Auer, D.F. Hansen, P. Neudecker, D.M. Korzhnev, D.R. Muhandiram, R. Konrat and Lewis E. Kay. Measurement of Signs of Chemical Shift Differences Between Ground and Excited Protein States: A Comparison Between H(S/M)QC and R Methods. J. Biomol. NMR 46, 205-216 (2010). Epub 22 Dec 2009. (313.pdf) (313_SI.doc) (DOI) (pubmed)

314.D.F. Hansen, P. Neudecker, P. Vallurupalli, F.A.A. Mulder and Lewis E. Kay. Determination of Leu Side-Chain Conformations in Excited Protein States by NMR Relaxation Dispersion. J. Am. Chem. Soc. 132, 42-43 (2010). Epub 11 Dec 2009. (314.pdf) (314_SI.pdf) (DOI) (pubmed)

315.T.L. Religa, R. Sprangers and Lewis E. Kay. Dynamic Regulation of Archaeal Proteasome Gate Opening as Studied by TROSY NMR. Science 328, 98-102 (2010). (315.pdf) (315_SI.pdf) (DOI) (pubmed)

316.M. Dey, A. Velyvis, J.J. Li, E. Chiu, D. Chiovitti, Lewis E. Kay, F. Sicheri, and T.E. Dever. Requirement for Kinase-Induced Conformational Change in Eukaryotic Initiation Factor 2α (eIF2α) Restricts Phosphorylation of Ser51. Proc. Natl. Acad. Sci. USA 108, 4316-4321 (2011). Epub 28 Feb 2011. (316.pdf) (316_SI.pdf) (DOI) (pubmed)

317.Lewis E. Kay. Structure and Dynamics of Proteins - Big and Small. In “eMagRes”. Eds. R.K. Harris, R.L. Wasylishen; J. Wiley (2010). Epub 15 Sep 2010. (317.pdf) (DOI)

318.T.L. Religa and Lewis E. Kay. Optimal Methyl Labeling for Studies of Supra-Molecular Systems. J. Biomol. NMR 47, 163-169 (2010). Epub 27 Apr 2010. (318.pdf) (318_SI.doc) (DOI) (pubmed)

319.G. Bouvignies, D.M. Korznev, P. Neudecker, D.F. Hansen, M.H.J. Cordes and Lewis E. Kay. A Simple Method for Measuring Signs of 1HN Chemical Shift Differences Between Ground and Excited Protein States. J. Biomol. NMR 47, 135-141 (2010). Epub 29 Apr 2010. (319.pdf) (319_SI.docx) (DOI) (pubmed)

320.D.F. Hansen, P. Neudecker and Lewis E. Kay. Determination of Isoleucine Side-Chain Conformations in Ground and Excited States of Proteins from Chemical Shifts. J. Am. Chem. Soc. 132, 7589-7591 (2010). Epub 13 May 2010. (320.pdf) (320_SI.pdf) (DOI) (pubmed)

321.A.M. Ruschak, T.L. Religa, S. Breuer, S. Witt and Lewis E. Kay. The Proteasome Antechamber Maintains Substrates in an Unfolded State. Nature 467, 868-871 (2010). Epub 13 Oct 2010. (321.pdf) (321_SI.tar) (DOI) (pubmed)

322.D.M. Korzhnev, T.L. Religa, W. Banachewicz, A.R. Fersht and Lewis E. Kay. A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution. Science 329, 1312-1316 (2010). (322.pdf) (322_SI.pdf) (DOI) (pubmed)

323.X. Li, T.E. Wood, R. Sprangers, G. Jansen, N.E. Franke, X. Mao, X. Wang, Y. Zhang, S.E. Verbrugge, H. Adomat, Z. Li, S. Trudel, C. Chen, T.L. Religa, N. Jamal, H. Messner, J. Cloos, D.R. Rose, A. Navon, R.A. Batey, Lewis E. Kay and A.D. Schimmer. Effect of Noncompetitive Proteasome Inhibition on Bortezomib Resistance. J. Natl. Cancer Inst. 102, 1069-1082 (2010). Epub 26 May 2010. (323.pdf) (323_SI.tar) (DOI) (pubmed)

324.A.J. Baldwin, T.L. Religa, D.F. Hansen, G. Bouvignies and Lewis E. Kay. 13CHD2 Methyl Group Probes of Millisecond Time Scale Exchange in Proteins by 1H Relaxation Dispersion: An Application to Proteasome Gating Residue Dynamics. J. Am. Chem. Soc. 132, 10992-10995 (2010). Epub 23 Jul 2010. (324.pdf) (324_SI.pdf) (DOI) (pubmed)

325.A.M. Ruschak, A. Velyvis and Lewis E. Kay. A Simple Strategy for 13C,1H Labeling at the Ile-γ2 Methyl Position in Highly Deuterated Proteins. J. Biomol. NMR 48, 129-135 (2010). Epub 14 Oct 2010. (325.pdf) (325_SI.pdf) (DOI) (pubmed)

326.E. Kupče, Lewis E. Kay and R. Freeman. Detecting the “Afterglow” of 13C NMR in Proteins Using Multiple Receivers. J. Am. Chem. Soc. 132, 18008-18011 (2010). Epub 2 Dec 2010. (326.pdf) (326_SI.pdf) (DOI) (pubmed)

327.A.M. Ruschak, M. Slassi, Lewis E. Kay and A.D. Schimmer. Novel Proteasome Inhibitors to Overcome Bortezomib Resistance. J. Natl. Cancer Inst. 103, 1007-1017 (2011). Epub 23 May 2011. (327.pdf) (DOI) (pubmed)

328.G. Bouvignies, D.F. Hansen, P. Vallurupalli and Lewis E. Kay. Divided-Evolution-Based Pulse Scheme for Quantifying Exchange Processes in Proteins: Powerful Complement to Relaxation Dispersion Experiments. J. Am. Chem. Soc. 133, 1935-1945 (2010). Epub 18 Jan 2011. (328.pdf) (328_SI.pdf) (DOI) (pubmed)

329.G. Bouvignies, P. Vallurupalli, M.H.J. Cordes, D.F. Hansen and Lewis E. Kay. Measuring 1HN Temperature Coefficients in Invisible Protein States by Relaxation Dispersion NMR Spectroscopy. J. Biomol. NMR 50, 13-18 (2011). Epub 18 Mar 2011. (329.pdf) (329_SI.docx) (DOI) (pubmed)

330.A.J. Baldwin, H. Lioe, C.V. Robinson, Lewis E. Kay and J.L.P. Benesch. αB-Crystallin Polydispersity is a Consequence of Unbiased Quaternary Dynamics. J. Mol. Biol. 413, 297-309 (2011). Epub 3 Aug 2011. (330.pdf) (330_SI.pdf) (DOI) (pubmed)

331.A.J. Baldwin, G.R. Hilton, H. Lioe, C. Bagnéris, J.L.P. Benesch and Lewis E. Kay. Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Local Fluctuations in the C-Terminus. J. Mol. Biol. 413, 310-320 (2011). Epub 3 Aug 2011. (331.pdf) (331_SI.pdf) (DOI) (pubmed)

332.H. Kato, H. van Ingen, B.-R. Zhou, H. Feng, M. Bustin, Lewis E. Kay and Y. Bai. Architecture of the High Mobility Group Nucleosomal Protein 2-Nucleosome Complex as Revealed Methyl-Based NMR. Proc. Natl. Acad. Sci. 108, 12283-12288 (2011). Epub 5 Jul 2011. (332.pdf) (332_SI.pdf) (DOI) (pubmed)

333.Lewis E. Kay. Solution NMR Spectroscopy of Supra-Molecular Systems, Why Bother? A Methyl-TROSY View. J. Magn. Reson. 210, 159-170 (2011). Epub 8 Mar 2011. (333.pdf) (DOI) (pubmed)

334.D.M. Korzhnev, R.M. Vernon, T.L. Religa, A.L. Hansen, D. Baker, A.R. Fersht and Lewis E. Kay. Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study. J. Am. Chem. Soc. 133, 10974-10982 (2011). Epub 28 Jun 2011. (334.pdf) (334_SI.pdf) (DOI) (pubmed)

335.D.F. Hansen and Lewis E. Kay. Determining Valine Side-Chain Rotamer Conformations in Proteins from Methyl 13C Chemical Shifts: Application to the 360 kDa Half-Proteasome. J. Am. Chem. Soc. 133, 8272-8281 (2011). Epub 5 May 2011. (335.pdf) (335_SI.pdf) (DOI) (pubmed)

336.G. Bouvignies, P. Vallurupalli, D.F. Hansen, B.E. Correia, O. Lange, A. Bah, R.M. Vernon, F.W. Dahlquist, D. Baker and Lewis E. Kay. Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant. Nature 477, 111-114 (2011). Epub 21 Aug 2021. (336.pdf) (336_SI.tar) (DOI) (pubmed)

337.T.L. Religa, A.M. Ruschak, R. Rosenzweig and Lewis E. Kay. Site-Directed Methyl Group Labeling as a Probe of Structure and Dynamics in Supramolecular Protein Systems: Applications to the Proteasome and to the ClpP Protease. J. Am. Chem. Soc. 133, 9063-9068 (2011). Epub 20 May 2011. (337.pdf) (DOI) (pubmed)

338.A.L. Hansen and Lewis E. Kay. Quantifying Millisecond Time-Scale Exchange in Proteins by CPMG Relaxation Dispersion Spectroscopy of Side-Chain Carbonyl Groups. J. Biomol. NMR 50, 347-355 (2011). Epub 18 Jun 2011. (338.pdf) (338_SI.pdf) (DOI) (pubmed)

339.Lewis E. Kay. NMR Studies of Protein Structure and Dynamics - A Look Backwards and Forwards. J. Magn. Reson. 213, 492-494 (2011). Epub 31 Aug 2011. (339.pdf) (DOI) (pubmed)

340.A.J. Baldwin, H. Lioe, G.R. Hilton, L.A. Baker, J.L. Rubinstein, Lewis E. Kay and J.L.P. Benesch. The Polydispersity of αB-Crystallin is Rationalized by an Interconverting Polyhedral Architecture. Structure 19, 1855-1863 (2011). Epub 6 Dec 2011. (340.pdf) (340_SI.pdf) (DOI) (pubmed)

341.P. Vallurupalli, G. Bouvignies and Lewis E. Kay. Increasing the Exchange Time-Scale that can be Probed by CPMG Relaxation Dispersion NMR. J. Phys. Chem. B 115, 14891-14900 (2011). Epub 11 Nov 2011. (341.pdf) (341_SI.pdf) (DOI) (pubmed)

342.J. Barette, A.Velyvis, T.L. Religa, D.M. Korzhnev and Lewis E. Kay. Cross-Validation of the Structure of a Transiently Formed and Low Populated FF Domain Folding Intermediate Determined by Relaxation Dispersion NMR and CS-Rosetta. J. Phys. Chem. B 116, 6637-6644 (2012). Epub 23 Dec 2011. (342.pdf) (342_SI.pdf) (DOI) (pubmed)

343.Lewis E. Kay. The Importance of Dynamics in Structural Biology. Nat. Struct. Mol. Biol. 18, 1308 (2011). Epub 5 Dec 2011. (343.pdf) (DOI)

344.H. Sun, Lewis E. Kay and V. Turgarinov. An Optimized Relaxation-Based Coherence Transfer NMR Experiment for the Measurement of Side-Chain Order in Methyl-Protonated, Highly Deuterated Proteins. J. Phys. Chem. B 115, 14878-14884 (2011). Epub 15 Nov 2011. (344.pdf) (DOI) (pubmed)

345.A.L. Hansen, P. Lundström, A. Velyvis and Lewis E. Kay. Quantifying Millisecond Exchange Dynamics in Proteins by CPMG Relaxation Dispersion NMR Using Side-Chain 1H Probes. J. Am. Chem. Soc. 134, 3178-3189 (2012). Epub 2 Feb 2012. (345.pdf) (345_SI.pdf) (DOI) (pubmed)

346.P. Neudecker, P. Robustelli, A. Cavalli, P. Walsh, P. Lundström, A. Zarrine-Afsar, S. Sharpe, M. Vendruscolo and Lewis E. Kay. Structure of an Intermediate State in Protein Folding and Aggregation. Science 336, 362-366 (2012). (346.pdf) (346_SI.pdf) (DOI) (pubmed)

347.A.J. Baldwin and Lewis E. Kay. Measurement of the Signs of Methyl 13C Chemical Shift Differences Between Interconverting Ground and Excited Protein States by R: An Application to αB-Crystallin. J. Biomol. NMR 53, 1-12 (2012). Epub 5 Apr 2012. (347.pdf) (347_SI.docx) (DOI) (pubmed)

348.P. Vallurupalli, G. Bouvignies and Lewis E. Kay. Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation. J. Am. Chem. Soc. 134, 8148-8161 (2012). Epub 3 May 2012. (348.pdf) (348_SI.pdf) (DOI) (pubmed)

349.D.M. Korzhnev, T.L. Religa and Lewis E. Kay. A Transiently Populated Intermediate Functions as a Branching Point of the FF Domain Folding Pathway. Proc. Natl. Acad. Sci. USA 109, 17777-17782 (2012). Epub 30 May 2012. (349.pdf) (349_SI.pdf) (DOI) (pubmed)

350.G. Bouvignies and Lewis E. Kay. A 2D 13C-CEST Experiment for Studying Slowly Exchanging Protein Systems Using Methyl Probes: An Application to Protein Folding. J. Biomol. NMR 53, 303-310 (2012). Epub 12 Jun 2012. (350.pdf) (350_SI.docx) (DOI) (pubmed)

351.A.J. Baldwin, P. Walsh, D.F. Hansen, G.R. Hilton, J.L.P. Benesch, S. Sharpe and Lewis E. Kay. Probing Dynamic Conformations of the High-Molecular-Weight αB-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy. J. Am. Chem. Soc. 134, 15343-15350 (2012). Epub 7 Sep 2012. (351.pdf) (351_SI.pdf) (DOI) (pubmed)

352.E. Kupče and Lewis E. Kay. Parallel Acquisition of Multi-Dimensional Spectra in Protein NMR. J. Biomol. NMR 54, 1-7 (2012). Epub 17 Jul 2012. (352.pdf) (DOI) (pubmed)

353.A.J. Baldwin and Lewis E. Kay. Structural Biology: Dynamic Binding. Nature 488, 165-166 (2012). Epub 8 Aug 2012. (353.pdf) (DOI) (pubmed)

354.J.L. Markley et al. In Support of the BMRB. Nat. Struct. Mol. Biol. 19, 854-860 (2012). (354.pdf) (DOI) (pubmed)

355.A. Velyvis, A.M. Ruschak and Lewis E. Kay. An Economical Method for Production of 2H,13CH3-Threonine for Solution NMR Studies of Large Protein Complexes: Application to the 670 kDa Proteasome. PloS One 7, e43725 (2012). Epub 11 Sept 2012. (355.pdf) (355_SI.doc) (DOI) (pubmed)

356.A. Sekhar, P. Vallurupalli and Lewis E. Kay. Folding of the Four-Helix Bundle FF Domain from a Compact On-Pathway Intermediate State is Governed Predominantly by Water Motion. Proc. Natl. Acad. Sci. USA 109, 19268-19273 (2012). Epub 5 Nov 2012. (356.pdf) (356_SI.pdf) (DOI) (pubmed)

357.A.J. Baldwin and Lewis E. Kay. An R Expression for a Spin in Chemical Exchange Between Two Sites with Unequal Transverse Relaxation Rates. J. Biomol. NMR 55, 211-218 (2013). Epub 23 Jan 2013. (357.pdf) (DOI) (pubmed)

358.A.M. Ruschak and Lewis E. Kay. Proteasome Allostery as a Population Shift Between Interchanging Conformers. Proc. Natl. Acad. Sci. USA 109, E3454-E3462 (2012). Epub 12 Nov 2012. (358.pdf) (356_SI.pdf) (DOI) (pubmed)

359.M.P. Latham and Lewis E. Kay. Is Buffer a Good Proxy for a Crowded Cell-Like Environment? A Comparative Study of Calmodulin Side-Chain Dynamics in Buffer and E. coli Lysate. PloS One 7, e48226 (2012). Epub 30 Oct 2012. (359.pdf) (DOI) (pubmed)

360.G. Bouvignies and Lewis E. Kay. Measurement of Proton Chemical Shifts in Invisible States of Slowly Exchanging Protein Systems by Chemical Exchange Saturation Transfer. J. Phys. Chem. B 116, 14311-14317 (2012). Epub 29 Nov 2012. (360.pdf) (360_SI.pdf) (DOI) (pubmed)

361.A. Mainz, T.L. Religa, R. Sprangers, R. Linser, Lewis E. Kay and B. Reif. NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond. Angew. Chem. Int. Ed. Engl. 52, 8746-8751 (2013). Epub 19 Jul 2013. (361.pdf) (361_SI.pdf) (DOI) (pubmed)

362.M.P. Latham and Lewis E. Kay. Probing Non-Specific Interactions of Ca2+-Calmodulin in E. coli Lysate. J. Biomol. NMR 55, 239-247 (2013). Epub 17 Jan 2013. (362.pdf) (DOI) (pubmed)

363.A.L. Hansen, G. Bouvignies and Lewis E. Kay. Probing Slowly Exchanging Protein Systems via 13Cα-CEST: Monitoring Folding of the Im7 Protein. J. Biomol. NMR 55, 279-289 (2013). Epub 6 Feb 2013. (363.pdf) (363_SI.docx) (DOI) (pubmed)

364.P. Vallurupalli and Lewis E. Kay. Probing Slow Chemical Exchange at Carbonyl Sites in Proteins by Chemical exchange Saturation Transfer NMR Spectroscopy. Angew. Chem. Int. Ed. Eng. 52, 4156-4159 (2013). Epub 28 Feb 2013. (364.pdf) (364_SI.pdf) (DOI) (pubmed)

365.M.T. Mazhab-Jafari, C.B. Marshall, P.B. Stathopulos, Y. Kobashigawa, V. Stambolic, Lewis E. Kay, F. Inagaki and M. Ikura. Membrane-Dependent Modulation of the mTOR Activator Rheb: NMR Observations of a GTPase Tethered to a Lipid-Bilayer Nanodisc. J. Am. Chem. Soc. 135, 3367-3370 (2013). Epub 20 Feb 2013. (365.pdf) (365_SI.pdf) (DOI) (pubmed)

366.R. Rosenzweig, S. Moradi, A. Zarrine-Afsar, J.R. Glover and Lewis E. Kay. Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction. Science 339, 1080-1083 (2013). Epub 7 Feb 2013. (366.pdf) (366_SI.tar) (DOI) (pubmed)

367.V. Tugarinov and Lewis E. Kay. Estimating Side-Chain Order in [U-2H;13CH3]-Labeled High Molecular Weight Proteins from Analysis of HMQC/HSQC Spectra. J. Phys. Chem. B 117, 3571-3577 (2013). Epub 25 Mar 2013. (367.pdf) (367_SI.pdf) (DOI) (pubmed)

368.A. Sekhar, P. Vallurupalli and Lewis E. Kay. Defining a Length Scale for Millisecond-Timescale Protein Conformational Exchange. Proc. Natl. Acad. Sci. USA 110, 11391-11396 (2013). Epub 25 Jun 2013. (368.pdf) (368_SI.pdf) (DOI) (pubmed)

369.A. Sekhar and Lewis E. Kay. NMR Paves the Way for Atomic Level Descriptions of Sparsely Populated, Transiently Formed Biomolecular Conformers. Proc. Natl. Acad. Sci. USA 110, 12867-12874 (2013). Epub 18 Jul 2013. (369.pdf) (DOI) (pubmed)

370.A. Velyvis and Lewis E. Kay. Measurement of Active Site Ionization Equilibria in the 670 kDa Proteasome Core Particle Using Methyl-TROSY NMR. J. Am. Chem. Soc. 135, 9259-9262 (2013). Epub 2 May 2013. (370.pdf) (370_SI.pdf) (DOI) (pubmed)

371.P. Vallurupalli, G. Bouvignies and Lewis E. Kay. A Computational Study of the Effects of 13C-13C Scalar Couplings on 13C CEST NMR Spectra: Towards Studies on a Uniformly 13C-Labeled Protein. Chembiochem 14, 1709-1713 (2013). Epub 19 Jun 2013. (371.pdf) (DOI) (pubmed)

372.G. Bouvignies, P. Vallurupalli and Lewis E. Kay. Visualizing Side Chains of Invisible Protein Conformers by Solution NMR. J. Mol. Biol. 426, 763-774 (2014). Epub 8 Nov 2013. (372.pdf) (372_SI.pdf) (DOI) (pubmed)

373.D. Long, C.B. Marshall, G. Bouvignies. M.T. Mazhab-Jafari, M.J. Smith, M. Ikura and Lewis E. Kay. A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues. Angew. Chem. Int. Ed. Engl. 52, 10771-10774 (2013). Epub 22 Aug 2013. (373.pdf) (DOI) (pubmed)

374.C.L. Pocanschi, S. Ehsani, M. Mehrabian, H. Wille, W. Reginold, W.S. Trimble, H. Wang, A. Yee, C.H. Arrowsmith, Z. Bozóky, Lewis E. Kay, J.D. Forman-Kay, J.M. Rini and G. Schmitt-Ulms. The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a Prp-Like Fold That Assembles into a Dimer. PloS One 8, e72446 (2013). Epub 6 Sep (2013). (374.pdf) (DOI) (pubmed)

375.R. Rosenzweig and Lewis E. Kay. Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR. Annu. Rev. Biochem. 83, 291-315 (2014). (375.pdf) (DOI) (pubmed)

376.L. Shi and Lewis E. Kay. Tracing an Allosteric Pathway Regulating the Activity of the HslV Protease. Proc. Natl. Acad. Sci. USA 111, 2140-2145 (2014). Epub 27 Jan 2014. (376.pdf) (376_SI.pdf) (DOI) (pubmed)

377.X. Wang, P. Vallurupalli, A. Vu, K. Lee, S. Sun, W.-J. Bai, C. Wu, H. Zhou, J.-E. Shea, Lewis E. Kay and F. W. Dahlquist. The Linker Between the Dimerization and Catalytic Domains of the CheA Histidine Kinase Propagates Changes in Structure and Dynamics That are Important for Enzymatic Activity. Biochemistry 53, 855-861 (2014). Epub 28 Jan 2014. (377.pdf) (377_SI.pdf) (DOI) (pubmed)

378.M.P. Latham, A. Sekhar and Lewis E. Kay. Understanding the Mechanism of Proteasome 20S Core Particle Gating. Proc. Natl. Acad. Sci. USA 111, 5532-5537 (2014). Epub 31 Mar 2014. (378.pdf) (378_SI.pdf) (DOI) (pubmed)

379.A. Sekhar, M.P. Latham, P. Vallurupalli and Lewis E. Kay. Viscosity-Dependent Kinetics of Protein Conformational Exchange: Microviscosity Effects and the Need for a Small Viscogen. J. Phys. Chem. B 118, 4546-4551 (2014). Epub 18 Apr 2014. (379.pdf) (DOI) (pubmed)

380.L. E. Kay and L. Frydman. A Special “JMR” Perspectives Issue: Foresights in Biomolecular Solution-State NMR Spectroscopy - From Spin Gymnastics to Structure and Dynamics. J. Magn. Reson. 241, 1-2 (2014). Epub 20 Mar 2014. (380.pdf) (DOI) (pubmed)

381.A.L. Hansen and Lewis E. Kay. Measurement of Histidine pKa Values and Tautomer Populations in Invisible Protein States. Proc. Natl. Acad. Sci. USA 111, E1705-E1712 (2014). Epub 14 Apr 2014. (381.pdf) (381_SI.pdf) (DOI) (pubmed)

382.C. Sanchez-Medina, A. Sekhar, P. Vallurupalli, M. Cerminara, V. Muñoz and Lewis E. Kay. Probing the Free Energy Landscape of the Fast-Folding gpW Protein by Relaxation Dispersion NMR. J. Am. Chem. Soc. 136, 7444-7451 (2014). Epub 8 May 2014. (382.pdf) (382_SI.pdf) (DOI) (pubmed)

383.D. Long, G. Bouvignies and Lewis E. Kay. Measuring Hydrogen Exchange Rates in Invisible Protein Excited States. Proc. Natl. Acad. Sci. USA 111, 8820-8825 (2014). Epub 2 Jun 2014. (383.pdf) (383_SI.pdf) (DOI) (pubmed)

384.A. Bah, R.M. Vernon, Z. Siddiqui, M. Krzeminski, R. Muhandiram, C. Zhao , N. Sonenberg, Lewis E. Kay and J.D. Forman-Kay. Folding of an Intrinsically Disordered Protein by Phosphorylation as a Regulatory Switch. Nature 519, 106-109 (2015). Epub 22 Dec 2014. (384.pdf) (384_SI.tar) (DOI) (pubmed)

385.M.P. Latham and Lewis E. Kay. A Similar In Vitro and In Cell Lysate Folding Intermediate for the FF Domain. J. Mol. Biol. 426, 3214-3220 (2014). Epub 30 Jul 2014. (385.pdf) (385_SI.docx) (DOI) (pubmed)

386.D. Long, A. Sekhar and Lewis E. Kay. Triple Resonance-Based 13Cα and 13Cβ CEST Experiments for Studies of ms Timescale Dynamics in Proteins. J. Biomol. NMR 60, 203-208 (2014). Epub 28 Oct 2014. (386.pdf) (386_SI.pdf) (DOI) (pubmed)

387.M.T. Mazhab-Jafari, C.B. Marshall, M.J. Smith, G.M.C. Gasmi-Seabrook, P.B. Stathopoulos, F. Inagaki, Lewis E. Kay, B.G. Neel, and M Ikura. Oncogenic and RASopathy-Associated K-RAS Mutations Relieve Membrane-Dependent Occlusion of the Effector-Binding Site. Proc. Natl. Acad. Sci USA 112, 6625-6630 (2015). Epub 4 May 2015. (387.pdf) (387_SI.pdf) (DOI) (pubmed)

388.A. Ahlner, C. Andresen, S.N. Khan, Lewis E. Kay and P. Lundström. Fractional Enrichment of Proteins using [2-13C]-Glycerol as the Carbon Source Facilitates Measurement of Excited State 13Cα Chemical Shifts with Improved Sensitivity. J. Biomol. NMR 62, 341-351 (2015). Epub 20 May 2015. (388.pdf) (388_SI.docx) (DOI) (pubmed)

389.A. Sekhar, J.A.O. Rumfeldt, H.R. Broom, C.M. Doyle, G. Bouvignies, E.M. Meiering and Lewis E. Kay. Thermal Fluctuations of Immature SOD1 Lead to Separate Folding and Misfolding Pathways. Elife 4, e07296 (2015). Epub 23 Jun 2015. (389.pdf) (DOI) (pubmed)

390.D. Long, F. Delaglio, A. Sekhar and Lewis E. Kay. Probing Invisible, Excited Protein States by Non-Uniformly Sampled Pseudo-4D CEST Spectroscopy. Angew. Chem. Int. Ed. Engl. 54, 10507-10511 (2015). Epub 15 Jul 2015. (390.pdf) (390_SI.pdf) (DOI) (pubmed)

391.A. Sekhar, R. Rosenzweig, G. Bouvignies and Lewis E. Kay. Mapping the Conformation of a Client Protein through the Hsp70 Functional Cycle. Proc. Natl. Acad. Sci. USA 112, 10395-103400 (2015). Epub 3 Aug 2015. (391.pdf) (391_SI.pdf) (DOI) (pubmed)

392.A. Sekhar, A.D. Bain, J.A.O. Rumfeldt, E.M. Meiering and Lewis E. Kay. Evolution of Magnetization Due to Asymmetric Dimerization: Theoretical Considerations and Application to Aberrant Oligomers Formed by apoSOD12SH. Phys. Chem. Chem. Phys. 18, 5720-5728 (2016). Epub 9 Jul 2015. (392.pdf) (DOI) (pubmed)

393.Z. Wang, P. Dove, A. Shamas-Din, Z. Li, A. Nachman, Y.J. Oh, R. Hurren, A. Ruschak, S. Climie, B. Press, C. Griffin, E. Undzys, A. Aman, R. Al-awar, Lewis E. Kay, D. O’Neill, S. Trudel, M. Slassi and A.D. Schimmer. FV-162 is a Novel, Orally Bioavailable, Irreversible Proteasome Inhibitor with Improved Pharmacokinetics Displaying Preclinical Efficacy with Continuous Daily Dosing. Cell Death Dis. 6, e1815 (2015). Epub 9 Jul 2015. (393.pdf) (393_SI.pdf) (DOI) (pubmed)

394.R. Rosenzweig, P. Farber, A. Veylvis, E. Rennella, M.P. Latham and Lewis E. Kay. The ClpB N-Terminal Domain Plays a Regulatory Role in Protein Disaggregation. Proc. Natl. Acad. Sci. USA 112, E6872-E6881 (2015). Epub 30 Nov 2015. (394.pdf) (394_SI.pdf) (DOI) (pubmed)

395.E. Rennella, R. Huang, A. Velyvis and Lewis E. Kay. 13CHD2-CEST NMR Spectroscopy Provides an Avenue for Studies of Conformational Exchange in High Molecular Weight Proteins. J. Biomol. NMR 63, 187-199 (2015). Epub 14 Aug 2015. (395.pdf) (DOI) (pubmed)

396.Lewis E. Kay. New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy. J. Mol. Biol. 428, 323-331 (2016). Epub 19 Dec 2015. (396.pdf) (DOI) (pubmed)

397.P. Vallurupalli, N. Chakrabarti, R. Pomès and Lewis E. Kay. Atomistic Picture of Conformational Exchange in a T4 Lysozyme Cavity Mutant: An Experiment-Guided Molecular Dynamics Study. Chem. Sci. 7, 3602-3613 (2015). Epub 7 Jan 2016. (397.pdf) (397_SI.tar) (DOI) (pubmed)

398.R. Rosenzweig and Lewis E. Kay. NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation. J. Am. Chem. Soc. 138, 1466-1477 (2016). Epub 29 Dec 2015. (398.pdf) (DOI) (pubmed)

399.C.M. Doyle, J.A. Rumfeldt, H.R. Broom, A. Sekhar, Lewis E. Kay and E.M. Meiering. Concurrent Increases and Decreases in Local Stability and Conformational Heterogeneity in Cu, Zn Superoxide Dismutase Variants Revealed by Temperature-Dependence of Amide Chemical Shifts. Biochemistry 55, 1346-1361 (2016). Epub 22 Feb 2016. (399.pdf) (399_SI.pdf) (DOI) (pubmed)

400.A. Sekhar, R. Rosenzweig, G. Bouvignies and Lewis E. Kay. Hsp70 Biases the Folding Pathways of Client Proteins. Proc. Natl. Acad. Sci. USA 113, E2794-E2801 (2016). Epub 2 May 2016. (400.pdf) (400_SI.pdf) (DOI) (pubmed)

401.S.W.S. Chan, J. Yau, C. Ing, K. Liu, P. Farber, A. Won, V. Bhandari, N. Kara-Yacoubian, T.V. Seraphim, N. Chakrabarti, Lewis E. Kay, C. Yip, R. Pomès, S. Sharpe and W.A. Houry. Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone. Structure 24, 1095-1109 (2016). Epub 2 Jun 2016. (401.pdf) (401_SI.tar) (DOI) (pubmed)

402.R. Huang, Z.A. Ripstein, R. Augustyniak, M. Laznieswki, K. Ginalski, Lewis E. Kay and J.L. Rubinstein. Unfolding the Mechanism of the AAA+ Unfoldase VAT by a Combined Cryo-EM, Solution NMR Study. Proc. Natl. Acad. Sci. USA 113, E4190-E4199 (2016). Epub 11 Jul 2016. (402.pdf) (402_SI.pdf) (DOI) (pubmed)

403.E. Rennella, A.K. Schuetz and Lewis E. Kay. Quantitative Measurement of Exchange Dynamics in Proteins via 13C Relaxation Dispersion of 13CHD2-Labeled Samples. J. Biomol. NMR 65, 59-64 (2016). Epub 1 Jun 2016. (403.pdf) (403_SI.pdf) (DOI) (pubmed)

404.A.N. Borkar, P. Vallurupalli, C. Camilloni, Lewis E. Kay and M. Vendruscolo. Simultaneous NMR Characterization of Multiple Minima in the Free Energy Landscape of an RNA UUCG Tetraloop. Phys. Chem. Chem. Phys. 19, 2797-2804 (2017). Epub 20 Dec 2016. (404.pdf) (404_SI.pdf) (DOI) (pubmed)

405.T. Yuwen, A. Sekhar and Lewis E. Kay. Evaluating the Influence of Initial Magnetization Conditions on Extracted Exchange Parameters in NMR Relaxation Experiments: Applications to CPMG and CEST. J. Biomol. NMR 65, 143-156 (2016). Epub 29 Jul 2016. (405.pdf) (405_SI.pdf) (DOI) (pubmed)

406.A.K. Schuetz and Lewis E. Kay. A Dynamic Molecular Basis for Malfunction in Disease Mutations of p97/VCP. Elife 5, e20143 (2016). Epub 9 Nov 2016. (406.pdf) (DOI) (pubmed)

407.T. Yuwen, P. Vallurupalli and Lewis E. Kay. Enhancing the Sensitivity of CPMG Relaxation Dispersion to Conformational Exchange Processes via Multiple-Quantum Spectroscopy. Angew. Chem. Int. Ed. Engl. 55, 11490-11494 (2016). Epub 16 Aug 2016. (407.pdf) (407_SI.pdf) (DOI) (pubmed)

408.A Sekhar, J.A.O. Rumfeldt, H.R. Broom, C.M. Doyle, R.E. Sobering, E.M. Meiering and Lewis E. Kay. Probing the Free Energy Landscapes of ALS Disease Mutants of SOD1 by NMR Spectroscopy. Proc. Natl. Acad. Sci. USA 113, E6939-E6945 (2016). Epub 24 Oct 2016. (408.pdf) (408_SI.pdf) (DOI) (pubmed)

409.T. Yuwen, A. Sekhar and Lewis E. Kay. Separating Dipolar and Chemical Exchange Magnetization Transfer in 1H-CEST. Angew. Chem. Int. Ed. Engl. 56, 6122-6125 (2017). Epub 30 Dec 2016. (409.pdf) (409_SI.pdf) (DOI) (pubmed)

410.E. Rennella, A. Sekhar and Lewis E. Kay. Self-Assembly of Human Profilin-1 Detected by Carr-Purcell-Meiboom-Gill Nuclear Magnetic Resonance (CPMG NMR) Spectroscopy. Biochemistry 56, 692-703 (2017). Epub 20 Jan 2017. (410.pdf) (410_SI.pdf) (DOI) (pubmed)

411.P. Vallurupalli, A. Sekhar, T. Yuwen and Lewis E. Kay. Probing Conformational Dynamics in Biomolecules via Chemical Exchange Saturation Transfer: A Primer. J. Biomol. NMR 67, 243-271 (2017). Epub 19 Mar 2017. (411.pdf) (DOI) (pubmed)

412.J. Kitevski-LeBlanc, A. Fradet-Turcotte, P. Kukic, M.D. Wilson, G. Portella, T. Yuwen, S. Panier, S. Duan, M.D. Canny, H. van Ingen, C.H. Arrowsmith, J.L. Rubinstein, M. Vendruscolo, D. Durocher and Lewis E. Kay. The RNF168 Paralog RNF169 Defines a New Class of Ubiquitylated Histone Reader Involved in the Response to DNA Damage. Elife 6, e23872 (2017). Epub 13 Apr 2017. (412.pdf) (DOI) (pubmed)

413.T. Yuwen and Lewis E. Kay. Longitudinal Relaxation Optimized Amide 1H-CEST Experiments for Studying Slow Chemical Exchange Processes in Fully Protonated Proteins. J. Biomol. NMR 67, 295-307 (2017). Epub 29 Mar 2017. (413.pdf) (413_SI.pdf) (DOI) (pubmed)

414.T. Yuwen, R. Huang and Lewis E. Kay. Probing Slow Timescale Dynamics in Proteins Using Methyl 1H-CEST. J. Biomol. NMR 68, 215-224 (2017). Epub 24 Jun 2017. (414.pdf) (414_SI.pdf) (DOI) (pubmed)

415.Z.A. Ripstein, R. Huang, R. Augustyniak, Lewis E. Kay and J.L. Rubinstein. Structure of a AAA+ Unfoldase in the Process of Unfolding Substrate. Elife 6, e25754 (2017). Epub 8 Apr 2017. (415.pdf) (DOI) (pubmed)

416.A. Malevanets, P.A. Chong, D.F. Hansen, P. Rizk, Y. Sun, H. Lin, R. Muhandiram, A. Chakrabartty, Lewis E. Kay, J. D. Forman-Kay and S.J. Wodak. Interplay of Buried Histidine Protonation and Protein Stability in Prion Misfolding. Sci. Rep. 7, 882 (2017). Epub 13 Apr 2017. (416.pdf) (416_SI.pdf) (DOI) (pubmed)

417.M. Chojnacki, W. Mansour, D.S. Hameed, R.K. Singh, F. El Oualid, R. Rosenzweig, M.A. Nakasone, Z. Yu, F. Glaser, Lewis E. Kay, D. Fushman, H. Ovaa and M.H. Glickman. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chem. Biol. 24, 443-457 (2017). Epub 16 Mar 2017. (417.pdf) (417_SI.tar) (DOI) (pubmed)

418.R. Rosenzweig, A. Sekhar, J. Nagesh and Lewis E. Kay. Promiscuous Binding by Hsp70 Results in Conformational Heterogeneity and Fuzzy Chaperone-Substrate Ensembles. Elife 6, e28030 (2017). Epub 14 Jul 2017. (418.pdf) (DOI) (pubmed)

419.R. Huang, J.P. Brady, A. Sekhar, T. Yuwen and Lewis E. Kay. An Enhanced Sensitivity Methyl 1H Triple-Quantum Pulse Scheme for Measuring Diffusion Constants of Macromolecules. J Biomol. NMR 68, 249-255 (2017). Epub 17 Jul 2017. (419.pdf) (419_SI.pdf) (DOI) (pubmed)

420.A.K. Schütz, E. Rennella and Lewis E. Kay. Exploiting Conformational Plasticity in the AAA+ Protein VCP/p97 to Modify Function. Proc. Nat. Acad. Sci. USA 114, E6822-E6829 (2017). Epub 31 Jul 2017. (420.pdf) (420_SI.pdf) (DOI) (pubmed)

421.A. Sekhar, J. Nagesh, R. Rosenzweig and Lewis E. Kay. Conformational Heterogeneity in the Hsp70 Chaperone-Substrate Ensemble Identified from Analysis of NMR-Detected Titration Data. Protein Sci. 26, 2207-2220 (2017). Epub 19 Aug 2017. (421.pdf) (421_SI.docx) (DOI) (pubmed)

422.J.P. Brady, P.J. Farber, A. Sekhar, Y.-H. Lin, R. Huang, A. Bah, T.J. Nott, H.S. Chan, A.J. Baldwin, J.D. Forman-Kay and Lewis E. Kay. Structural and Hydrodynamic Properties of an Intrinsically Disordered Region of a Germ Cell-Specific Protein on Phase Separation. Proc. Nat. Acad. Sci. USA 114, E8194-E8203 (2017). Epub 11 Sep 2017. (422.pdf) (422_SI.pdf) (DOI) (pubmed)

423.R. Huang, F. Pérez and Lewis E. Kay. Probing the Cooperativity of Thermoplasma acidophilum Proteasome Core Particle Gating by NMR Spectroscopy. Proc. Nat. Acad. Sci. USA 114, E9846-E9854 (2017). Epub 30 Oct 2017. (423.pdf) (423_SI.pdf) (DOI) (pubmed)

424.T. Yuwen, J.P. Brady and Lewis E. Kay. Probing Conformational Exchange in Weakly Interacting, Slowly Exchanging Systems via Off-Resonance R Experiments: Application to Studies of Protein Phase Separation. J. Am. Chem. Soc. 140, 2115-2126 (2018). Epub 31 Jan 2018. (424.pdf) (424_SI.pdf) (DOI) (pubmed)

425.A. Sekhar, A. Velyvis, G. Zoltsman, R. Rosenzweig, G. Bouvignies and Lewis E. Kay. Conserved Conformational Selection Mechanism of Hsp70 Chaperone-Substrate Interactions. Elife 7, e32764 (2018). Epub 20 Feb 2018. (425.pdf) (DOI) (pubmed)

426.T. Yuwen and Lewis E. Kay. A New Class of CEST Experiment Based on Selecting Different Magnetization Components at the Start and End of the CEST Relaxation Element: An Application to 1H CEST. J Biomol. NMR 70, 93-102 (2018). Epub 19 Jan 2018. (426.pdf) (426_SI.pdf) (DOI) (pubmed)

427.R.M. Culik, A. Sekhar, J. Nagesh, H. Deol, J.A.O. Rumfeldt, E.M. Meiering and Lewis E. Kay. The Effects of Maturation on the Conformational Free-Energy Landscape of SOD1. Proc. Nat. Acad. Sci. USA 115, E2546-E2555 (2018). Epub 26 Feb 2018. (427.pdf) (427_SI.pdf) (DOI) (pubmed)

428.J. Mondal, N. Ahalawat, S. Pandit, Lewis E. Kay and P. Vallurupalli. Atomic Resolution Mechanism of Ligand Binding to a Solvent Inaccessible Cavity in T4 Lysozyme. PLoS Comput. Biol. 14, e1006180 (2018). Epub 18 May 2018. (428.pdf) (428_SI.pdf) (DOI) (pubmed)

429.R. Augustyniak and Lewis E Kay. Cotranslational Processing of the Protein Substrate Calmodulin by a AAA+ Unfoldase Occurs via Unfolding and Refolding Intermediates. Proc. Natl. Acad. Sci USA 115, E4786-E4795 (2018). Epub 7 May 2018. (429.pdf) (429_SI.pdf) (DOI) (pubmed)

430.J.L. Kitevski-LeBlanc, T. Yuwen, P.N. Dyer, J. Rudolph, K. Lugar and Lewis E. Kay. Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR. J. Am. Chem. Soc. 140, 4774-4777 (2018). Epub 28 Mar 2018. (430.pdf) (430_SI.pdf) (DOI) (pubmed)

431.Lewis E. Kay. A Magnetic Moment Silenced: A Tribute to My Friend and Mentor Alex D. Bain. Concepts Magn. Reson. 45A, e21420 (2018). Epub 29 Apr 2018. (431.pdf) (DOI)

432.T. Yuwen, Lewis E. Kay and G. Bouvignies. Dramatic Decrease in CEST Measurement Times Using Multi-Site Excitation. Chemphyschem. 19, 1707-1710 (2018). Epub 17 Apr 2018. (432.pdf) (432_SI.pdf) (DOI) (pubmed)

433.T. Yuwen, G. Bouvignies and Lewis E. Kay. Exploring Methods to Expedite the Recording of CEST Datasets Using Selective Pulse Excitation. J. Magn. Reson. 292, 1-7 (2018). Epub 26 Apr 2018. (433.pdf) (433_SI.pdf) (DOI) (pubmed)

434.S. Vahidi, Z.A. Ripstein, M. Bonomi, T. Yuwen, M.F. Mabanglo, J.B. Juravsky, K. Rizzolo, A. Velyvis, W.A. Houry, M. Vendruscolo, J.L. Rubinstein and Lewis E. Kay. Reversible Inhibition of the ClpP Protease via an N-Terminal Conformational Switch. Proc. Natl. Acad. Sci. USA 115, E6447-E6456 (2018). Epub 25 Jun 2018. (434.pdf) (434_SI.pdf) (DOI) (pubmed)

435.J. Boisbouvier and Lewis E. Kay. Advanced Isotopic Labeling for the NMR Investigation of Challenging Proteins and Nucleic Acids. J. Biomol. NMR 71, 115-117 (2018). Epub 24 Jul 2018. (435.pdf) (DOI) (pubmed)

436.A.B. Gopalan, T. Yuwen, Lewis E. Kay and P. Vallurupalli. A Methyl 1H Double Quantum CPMG Experiment to Study Protein Conformational Exchange. J. Biomol. NMR 72, 79-91 (2018). Epub 1 Oct 2018. (436.pdf) (436_SI.pdf) (DOI) (pubmed)

437.T. Yuwen, A. Bah, J.P. Brady, F. Ferrage, G. Bouvignies and Lewis E. Kay. Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation. J. Phys. Chem. B 122, 11206-11217 (2018). Epub 4 Sep 2018. (437.pdf) (437_SI.pdf) (DOI) (pubmed)

438.T. Yuwen, A. Sekhar, A.J. Baldwin, P. Vallurupalli and Lewis E. Kay. Measuring Diffusion Constants of Invisible Protein Conformers by Triple-Quantum 1H CPMG Relaxation Dispersion. Angew. Chem. Int. Ed. Engl. 57, 16777-16780 (2018). Epub 29 Oct 2018. (438.pdf) (438_SI.pdf) (DOI) (pubmed)

439.R. Huang, Z.A. Ripstein, J.L. Rubinstein and Lewis E. Kay. Cooperative Subunit Dynamics Modulate p97 Function. Proc. Natl. Acad. Sci. USA 116, 158-167 (2019). Epub 24 Dec 2018. (439.pdf) (439_SI.pdf) (DOI) (pubmed)

440.E. Rennella, G.J. Morgan, J.W. Kelly and Lewis E. Kay. Role of Domain Interactions in the Aggregation of Full-Length Immunoglobulin Light Chains. Proc. Natl. Acad. Sci. USA 116, 854-863 (2019). Epub 31 Dec 2018. (440.pdf) (440_SI.pdf) (DOI) (pubmed)

441.A. Sekhar and Lewis E. Kay. An NMR View of Protein Dynamics in Health and Disease. Annu. Rev. Biophys. 48, 297-319 (2019). Epub 22 Mar 2019. (441.pdf) (DOI) (pubmed)

442.Lewis E. Kay. Artifacts Can Emerge in Spectra Recorded with Even the Simplest of Pulse Schemes: an HMQC Case Study. J. Biomol. NMR 73, 423-427 (2019). Epub 23 Feb 2019. (442.pdf) (DOI) (pubmed)

443.T. Yuwen, R. Huang, P. Vallurupalli and Lewis E. Kay. A Methyl-TROSY-Based 1H Relaxation Dispersion Experiment for Studies of Conformational Exchange in High Molecular Weight Proteins. Angew. Chem. Int. Ed. Engl. 58, 6250-6254 (2019). Epub 7 Mar 2019. (443.pdf) (443_SI.pdf) (DOI) (pubmed)

444.G.J. Morgan, N.L. Yan, D.E. Mortenson, E. Rennella, J.M. Blundon, R.M. Gwin, C.-Y. Lin, R.L. Stanfield, S.J. Brown, H. Rosen, T.P. Spicer, V. Fernandez-Vega, G. Merlini, Lewis E. Kay, I.A. Wilson and J.W. Kelly. Stabilization of Amyloidogenic Immunoglobulin Light Chains by Small Molecules. Proc. Natl. Acad. Sci. USA 116, 8360-8369 (2019). Epub 10 Apr 2019. (444.pdf) (444_SI.pdf) (DOI) (pubmed)

445.Lewis E. Kay. The Evolution of Solution State NMR Pulse Sequences Through the ‘Eyes’ of Triple-Resonance Spectroscopy. J. Magn. Reson. 306, 48-54 (2019). Epub 12 Jul 2019. (445.pdf) (DOI) (pubmed)

446.E. Rennella, G.J. Morgan, N. Yan, J.W. Kelly and Lewis E. Kay. The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains. J. Am. Chem. Soc. 141, 13562-13571 (2019). Epub 31 Jul 2019. (446.pdf) (446_SI.pdf) (DOI) (pubmed)

447.T.H. Kim, B. Tsang, R.M. Vernon, N. Sonenberg, Lewis E. Kay and J.D. Forman-Kay. Phospho-Dependent Phase Separation of FMRP and CAPRIN1 Recapitulates Regulation of Translation and Deadenylation. Science 365, 825-829 (2019). (447.pdf) (447_SI.tar) (DOI) (pubmed)

448.T.R. Alderson and Lewis E. Kay. Unveiling Invisible Protein States with NMR Spectroscopy. Curr. Opin. Struct. Biol. 60, 39-49 (2020). Epub 11 Dec 2019. (448.pdf) (DOI) (pubmed)

449.T. Yuwen and Lewis E. Kay. Revisiting 1HN CPMG Relaxation Dispersion Experiments: a Simple Modification Can Eliminate Large Artifacts. J. Biomol. NMR 73, 641-650 (2019). Epub 23 Oct 2019. (449.pdf) (449_SI.pdf) (DOI) (pubmed)

450.Z.A. Ripstein, S. Vahidi, W.A. Houry, J.L. Rubinstein and Lewis E. Kay. A Processive Rotary Mechanism Couples Substrate Unfolding and Proteolysis in the ClpXP Degradation Machinery. Elife 9, e52158 (2020). Epub 9 Jan 2020. (450.pdf) (450_SI.jpg) (DOI) (pubmed)

451.Lewis E. Kay. A Tribute to James H. Prestegard - 75 Years Young! J. Magn. Reson. 310, 106616 (2020). Epub 8 Oct 2019. (451.pdf) (DOI) (pubmed)

452.L.E. Wong, T.H. Kim, D.R. Muhandiram, J.D. Forman-Kay, and Lewis E. Kay. NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1. J. Am. Chem. Soc. 142, 2471-2489 (2020). Epub 21 Jan 2020. (452.pdf) (452_SI.pdf) (DOI) (pubmed)

453.M.F. Mabanglo, E. Leung, S. Vahidi, T.V. Seraphim, B.T. Eger, S. Bryson, V. Bhandari, J.L. Zhou, Y.-Q. Mao, K. Rizzolo, M.M. Barghash, J.D. Goodreid, S. Phanse, M. Babu, L.R.S. Barbosa, C.H.I. Ramos, R.A. Batey, Lewis E. Kay, E.F. Pai and W.A. Houry. ClpP Protease Activation Results from the Reorganization of the Electrostatic Interaction Networks at the Entrance Pores. Commun. Biol. 2, 410 (2019). Epub 13 Nov 2019. (453.pdf) (453_SI.tar) (DOI) (pubmed)

454.E. Rennella, R. Huang, Z. Yu and Lewis E. Kay. Exploring Long-Range Cooperativity in the 20S Proteasome Core Particle from Thermoplasma acidophilum using Methyl-TROSY-Based NMR. Proc. Natl. Acad. Sci. USA 117, 5298-5309 (2020). Epub 24 Feb 2020. (454.pdf) (454_SI.pdf) (DOI) (pubmed)

455.S. Vahidi, Z.A. Ripstein, J.B. Juravsky, E. Rennella, A.L. Goldberg, A.K. Mittermaier, J.L. Rubinstein, and Lewis E. Kay. An Allosteric Switch Regulates Mycobacterium tuberculosis ClpP1P2 Protease Function as Established by Cryo-EM and Methyl-TROSY NMR. Proc. Natl. Acad. Sci. USA 117, 5895-5906 (2020). Epub 2 Mar 2020. (455.pdf) (455_SI.pdf) (DOI) (pubmed)

456.N. Kessler, S.R. Akabayov, A. Moseri, L.S. Cohen, D. Sakhapov, D. Bolton, B. Fridman, Lewis E. Kay, F. Naider and J. Anglister. Allovalency Observed by Transferred NOE: Interactions of Sulfated Tyrosine Residues in the N-Terminal Segment of CCR5 with CCL5 Chemokine. FEBS J. 288, 1648-1663 (2021). Epub 19 Aug 2020. (456.pdf) (DOI) (pubmed)

457.L.E. Wong, T.H. Kim, E. Rennella, P. Vallurupalli, and Lewis E. Kay. Confronting the Invisible: Assignment of Protein 1HN Chemical Shifts in Cases of Extreme Broadening. J. Phys. Chem. Lett. 11, 3384-3389 (2020). Epub 14 Apr 2020. (457.pdf) (457_SI.pdf) (DOI) (pubmed)

458.G. Abramov, A. Velyvis, E. Rennella, L.E. Wong and Lewis E. Kay. A Methyl-TROSY Approach for NMR Studies of High-Molecular-Weight DNA with Application to the Nucleosome Core Particle. Proc. Natl. Acad. Sci. USA 117, 12836-12846 (2020). Epub 26 May 2020. (458.pdf) (458_SI.pdf) (DOI) (pubmed)

459.S. Kumar, S.R. Akabayov, N. Kessler, L.S. Cohen, J. Solanki, F. Naider, Lewis E. Kay and J. Anglister. The Methyl 13C-Edited/13C-Filtered Transferred NOE for Studying Protein Interactions with Short Linear Motifs. J. Biomol. NMR 74, 681-693 (2020). Epub 30 Sep 2020. (459.pdf) (459_SI.pdf) (DOI) (pubmed)

460.N. Yan, D. Santos-Martins, E. Rennella, B.B. Sanchez, J.S. Chen, Lewis E. Kay, I.A. Wilson, G.J. Morgan, S. Forli, J.W. Kelly. Structural Basis for the Stabilization of Amyloidogenic Immunoglobulin Light Chains by Hydantoins. Bioorg. Med. Chem. Lett. 30, 127356 (2020). Epub 16 Jun 2020. (460.pdf) (460_SI.docx) (DOI) (pubmed)

461.R.W. Harkness, Y. Toyama, and Lewis E. Kay. Analyzing Multi-Step Ligand Reactions for Oligomeric Proteins by NMR: Theoretical and Computations Considerations. J. Magn. Reson. 318, 106802 (2020). Epub 4 Aug 2020. (461.pdf) (DOI) (pubmed)

462.A.E. Conicella, R. Huang, Z.A. Ripstein, A. Nguyen, E. Wang, T. Löhr, P. Schuck, M. Vendruscolo, J.L. Rubinstein and Lewis E. Kay. An Intrinsically Disordered Motif Regulates the Interaction Between the p47 Adaptor and the p97 AAA+ ATPase. Proc. Natl. Acad. Sci. USA 117, 26226-26236 (2020). Epub 7 Oct 2020. (462.pdf) (462_SI.pdf) (DOI) (pubmed)

463.R. Huang, Z.A. Ripstein, J.L. Rubinstein and Lewis E. Kay. Probing Cooperativity of N-Terminal Domain Orientations in the p97 Molecular Machine: Synergy Between NMR and Cryo-EM. Angew. Chem. Int. Ed. Engl. 59, 22423-22426 (2020). Epub 28 Aug 2020. (463.pdf) (463_SI.pdf) (DOI) (pubmed)

464.Z.A. Ripstein, S. Vahidi, J.L. Rubinstein and Lewis E. Kay. A pH-Dependent Conformational Switch Controls N. meningitidis ClpP Protease Function. J. Am. Chem. Soc. 142, 20519-20523 (2020). Epub 24 Nov 2020. (464.pdf) (464_SI.pdf) (DOI) (pubmed)

465.T.R. Alderson and Lewis E. Kay. NMR Spectroscopy Captures the Essential Role of Dynamics in Regulating Biomolecular Function. Cell 184, 577- 595 (2021). (465.pdf) (465_SI.doc) (DOI) (pubmed)

466.Y. Toyama, R.W. Harkness, T.Y.T. Lee, J.T. Maynes and Lewis E. Kay. Oligomeric Assembly Regulating Mitochondrial HtrA2 Function as Examined by Methyl-TROSY NMR. Proc. Natl. Acad. Sci. USA 118, e2025022118 (2021). Epub 10 Mar 2021. (466.pdf) (466_SI.pdf) (DOI) (pubmed)

467.Lewis E. Kay. A Life Writ Large: Chris Dobson 1949-2019. J. Magn. Reson. 326, 106947 (2021). Epub 18 Feb 2021. (467.pdf) (DOI) (pubmed)

468.A. Parupudi, S.K. Chaturvedi, R. Adão, R.W. Harkness, S. Dragulin-Otto, Lewis E. Kay, R. Esfandiary, H. Zhao and P Schuck. Global Multi-Method Analysis of Interaction Parameters for Reversibly Self-Associating Macromolecules at High Concentrations. Sci. Rep. 11, 5741 (2021). Epub 11 Mar 2021. (468.pdf) (468_SI.pdf) (DOI) (pubmed)

469.T.H. Kim, B.J. Payliss, M.L. Nosella, I.T.W. Lee, Y. Toyama, J.D. Forman-Kay and Lewis E. Kay. Interaction Hot Spots for Phase Separation Revealed by NMR Studies of a CAPRIN1 Condensed Phase. Proc. Natl. Acad. Sci. USA 118, e2104897118 (2021). Epub 31 May 2021. (469.pdf) (469_SI.pdf) (DOI) (pubmed)

470.C.R. Knoverek, U.L. Mallimadugula, S. Singh, E. Rennella, T.E. Frederick, T. Yuwen, S. Raavicharla, Lewis E. Kay and G.R. Bowman. Opening of a Cryptic Pocket in β-Lactamase Increases Penicillinase Activity. Proc. Natl. Acad. Sci. USA 118, e2106473118 (2021). Epub 19 Nov 2021. (470.pdf) (470_SI.pdf) (DOI) (pubmed)

471.R.W. Harkness, Y. Toyama, Z.A. Ripstein, H. Zhao, A.I.M. Sever, Q. Luan, J.P. Brady, P.L. Clark, P. Schuck and Lewis E. Kay. Competing Stress-Dependent Oligomerization Pathways Regulate Self-Assembly of the Periplasmic Protease-Chaperone DegP. Proc. Natl. Acad. Sci. USA 118, e2109732118 (2021). Epub 6 Aug 2021. (471.pdf) (471_SI.pdf) (DOI) (pubmed)

472.Y. Toyama, R.W. Harkness and Lewis E. Kay Dissecting the Role of Interprotomer Cooperativity in the Activation of Oligomeric High-Temperature Requirement A2 protein. Proc. Natl. Acad. Sci. USA 118, e2111257118 (2021). Epub 26 Aug 2021. (472.pdf) (472_SI.pdf) (DOI) (pubmed)

473.V.P. Tiwari, Y. Toyama, D. De, Lewis E. Kay and P. Vallurupalli. The A39G FF Domain Folds on a Volcano-Shaped Free Energy Surface via Separate Pathways. Proc. Natl. Acad. Sci. USA 118, e2115113118 (2021). Epub 10 Nov 2021. (473.pdf) (473_SI.pdf) (DOI) (pubmed)

474.Y. Toyama and Lewis E. Kay. Probing Allosteric Interactions in Homo-Oligomeric Molecular Machines using Solution NMR Spectroscopy. Proc. Natl. Acad. Sci. USA 118, e2116325118 (2021). Epub 10 Dec 2021. (474.pdf) (DOI) (pubmed)

475.Y. Toyama, R.W. Harkness and Lewis E. Kay. Structural Basis of Protein Substrate Processing by Human Mitochondrial High-Temperature Requirement A2 Protease. Proc. Natl. Acad. Sci. USA 119, e2203172119 (2022). Epub 22 Apr 2022. (475.pdf) (475_SI.pdf) (DOI) (pubmed)

476.G. Karunanithy, T. Yuwen, Lewis E. Kay and D.F. Hansen. Towards Autonomous Analysis of Chemical Exchange Saturation Transfer Experiments using Deep Neural Networks. J. Biomol. NMR 76, 75-86 (2022). Epub 27 May 2022. (476.pdf) (476_SI.pdf) (DOI) (pubmed)

477.Y. Toyama and Lewis E. Kay. Revisiting Dipolar Relaxation of a Homonuclear Spin Pair in the Presence of a Radio Frequency Field: A Tutorial. J. Mag. Reson. Open 12-13, 100065 (2022). Epub 15 Jul 2022. (477.pdf) (477_SI.docx) (DOI)

478.Y. Toyama, A.K. Rangadurai and Lewis E. Kay. Measurement of 1Hα Transverse Relaxation Rates in Proteins: Application to Solvent PREs. J. Biomol. NMR 76, 137-152 (2022). Epub 26 Aug 2022. (478.pdf) (DOI) (pubmed)

479.N. Bolik-Coulon, D.F. Hansen, and Lewis E. Kay. Optimizing Frequency Sampling in CEST Experiments. J. Biomol. NMR 76, 167-183 (2022). Epub 4 Oct 2022. (479.pdf) (479_SI.pdf) (DOI) (pubmed)

480.Y. Toyama, A.K. Rangadurai, J.D. Forman-Kay and Lewis E. Kay. Mapping the Per-Residue Surface Electrostatic Potential of CAPRIN1 During its Phase-Separation Trajectory. Proc. Natl. Acad. Sci. USA 119, e2210492119 (2022). Epub 30 Aug 2022. (480.pdf) (480_SI.pdf) (DOI) (pubmed)

481.Lewis E. Kay and T. Carlomagno. Editorial for Kurt Wüthrich JMR Celebratory Issue. J. Magn. Reson. 343, 107296 (2022). Epub 5 Sep 2022. (481.pdf) (DOI) (pubmed)

482.N. Bolik-Coulon, A.I.M. Sever, R.W. Harkness, J.M. Aramini, Y. Toyama, D.F. Hansen and Lewis E. Kay. Less is more: A Simple Methyl-TROSY Based Pulse Scheme Offers Improved Sensitivity in Applications to High Molecular Weight Complexes. J. Magn. Reson. 346, 107326 (2023). Epub 9 Nov 2022. (482.pdf) (482_SI.pdf) (DOI) (pubmed)

483.Y. Toyama, A.K. Rangadurai, J.D. Forman-Kay and Lewis E. Kay. Surface Electrostatics Dictate RNA-Binding Protein CAPRIN1 Condensate Concentration and Hydrodynamic Properties. J. Biol. Chem. 299, 102776 (2022). Epub 7 Dec 2022. (483.pdf) (DOI) (pubmed)

484.A.K. Rangadurai, Y. Toyama and Lewis E. Kay. Practical Considerations for the Measurement of Near-Surface Electrostatics based on Solvent Paramagnetic Relaxation Enhancements. J. Magn. Reson. 349, 107400 (2023). Epub 9 Feb 2023. (484.pdf) (484_SI.docx) (DOI) (pubmed)

485.A.K. Rangadurai, Y. Toyama and Lewis E. Kay. Sometimes Pulses Just Have to be Perfect - An Example Based on the Measurement of Amide Proton Transverse Relaxation Rates in Proteins. J. Magn. Reson. 349, 107412 (2023). Epub 2 Mar 2023. (485.pdf) (485_SI.docx) (DOI) (pubmed)

486.S. Nim, D.M. O’Hara, C. Corbi-Verge, A. Perez-Riba, K. Fujisawa, M. Kapadia, H. Chau, F. Albanese, G. Pawar, M.L. De Snoo, S.G. Ngana, J. Kim, O.M.A. El-Agnaf, E. Rennella, Lewis E. Kay, S.K. Kalia, L.V. Kalia and P.M. Kim. Disrupting the α-synuclein-ESCRT Interaction with a Peptide Inhibitor Mitigates Neurodegeneration in Preclinical Models of Parkinson’s Disease. Nat. Commun. 14, 2150 (2023). Epub 19 Apr 2023. (486.pdf) (486_SI.pdf) (DOI) (pubmed)

487.R.W. Harkness, Z.A. Ripstein, J.M. Di Trani and Lewis E Kay. Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J. Am. Chem. 145, 13015-13026 (2023). Epub 7 Jun 2023. (487.pdf) (487_SI.pdf) (DOI) (pubmed)

488.T.H. Kim, M.L. Nosella, N. Bolik-Coulon, R.W. Harkness, S.K. Huang and Lewis E. Kay. Correlating Histone Acetylation with Nucleosome Core Particle Dynamics and Function. Proc. Natl. Acad. Sci. USA 120, e2301063120 (2023). Epub 3 Apr 2023. (488.pdf) (488_SI.pdf) (DOI) (pubmed)

489.E. Rennella, D.D. Sahtoe, D. Baker and Lewis E. Kay. Exploiting Conformational Dynamics to Modulate the Function of Designed Proteins. Proc. Natl. Acad. Sci. USA 120, e2303149120 (2023). Epub 24 Apr 2023. (489.pdf) (489_SI.pdf) (DOI) (pubmed)

490.A.I.M. Sever, T.R. Alderson, E. Rennella, J.M. Aramini, Z.H. Liu, R.W. Harkness and Lewis E. Kay. Activation of Caspase-9 on the Apoptosome as Studied by Methyl-TROSY NMR. Proc. Natl. Acad. Sci. USA 120, e2310944120 (2023). Epub 12 Dec 2023. (490.pdf) (490_SI.pdf) (DOI) (pubmed)

491.V.P. Tiwari, D. De, N. Thapliyal, Lewis E. Kay and P. Vallurupalli. Beyond Slow Two-State Protein Conformational Exchange Using CEST: Applications to Three-State Protein Interconversion on the Millisecond Timescale. J. Biomol. NMR 78, xx-yy (2024). Epub 3 Jan 2024. (491.pdf) (491_SI.pdf) (DOI) (pubmed)

492.M.L. Nosella, T.H. Kim, S.K. Huang, R.W. Harkness, M. Goncalves, A. Pan, M. Tereshchenko, S. Vahidi, J.L. Rubinstein, H.O. Lee, J.D. Forman-Kay and Lewis E. Kay. Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates. Mol. Cell 84, 1-18 (2024). Epub 8 Jan 2024. (492.pdf) (492_SI.zip) (DOI) (pubmed)

493.D.D. Sahtoe, E.A. Andrzejewska, H.L. Han, E. Rennella, M.M. Schneider, G. Meisl, H. Choi, M. Ahlrichs, J. Decarreau, H. Nguyen, X. Li, A.K. Bera, Lewis E. Kay, T.P.J. Knowles and D. Baker. Design of Amyloidogenic Peptide Traps. In Press.



last updated: 15 Jan 2024 / jma